Evrim ÇAKIR, MEHMET SAİT DOĞAN, Mustafa GÖKHAN VURAL, Uğur ARSLANTAŞ, Sadık AÇIKEL, Ekrem YETER, Tuncay DELİBAŞI, Tolga ÇİMEN

İdyopatik hirşutizm hastalarında QT dispersiyonu

Amaç: Çalışmada idyopatik hirşutizm tanılı hastaların QT dispersiyonu açısından değerlendirilmesi amaçlanmıştır. Metod: 28 İH hastası ve kontrol grubu olarak 35 sağlıklı kadın çalışmaya dahil edildi. Hastaların hormonal incelemeleri ile birlikte elektrokardiyografi (EKG) analizleri yapılarak QT dispersiyonları(QTd) ile düzeltilmiş QT(QTc) değerleri kullanılarak düzeltilmiş QT dispersiyon(QTcd) değerleri elde edilmiştir. Bulgular: İH ve kontrol hastalarının minimum QT (336±30; 337±32 ms), maksimum QT (358±30; 358±34 ms), minimum QTc (391 ± 24; 399 ± 25 ms); maksimum QTc (417 ± 24; 424 ± 26 ms), QTd (22±5; 21±7, P=0.6) ve QTcd (26 ± 6, 25 ± 9 ms, P= 0.7) değerleri arasındaki fark istatistiksel olarak anlamsızdı. Hirşutizm hastalarında açlık insülin, Homeostasis model assessment (HOMA) indeksi ve androjen düzeyleri anlamlı olarak yüksek saptandı. Sonuç: Hormonal ve metabolik bozukluklara rağmen İH hastalarında sağlıklı kadınlara göre anlamlı QT dispersiyonu saptanmamıştır

QT dispertion in patients with idiopathic hirsutism

Objective: Our study purposed to evaluate QT dispertion in idiopathic hirsutism (IH) patients. Method: Study included 28 IH patient and 35 healty women as control group. Patient's hormonal workups and electrocardiograms (ECG) analyzed and QT dispertion (QTd) and corrected QT dispertion (QTcd) values were calculated. Results: Minimum QT (336±30; 337±32 ms), maximum QT (358±30; 358±34 ms), minimum QTc (391 ± 24; 399 ± 25 ms); maximum QTc (417 ± 24; 424 ± 26 ms), QTd (22±5; 21±7, P=0.6) and QTcd (26 ± 6, 25 ± 9 ms, P= 0.7) values were not significantly different between IH and healthy women. Fasting insulin, Homeostasis model assessment (HOMA) index and androgen levels were significantly high in IH patients. Conclusion: Despite differences in hormonal and metabolic pattern, our data demonstrate no significant difference in ECG pattern in IH compared to healthy controls

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