SİNAN DEMİRCİOĞLU, Handan CİPİL, ÖZCAN ÇENELİ, Aynur Uğur BİLGİN

İbrutinib sonrası gelişen dev ekimoz ve hematom: olgu sunumu

Kronik lenfositik lösemi ve Mantle hücreli lenfoma da yeni bir tedavi seçeneği olan ibrutinib, yüksek etkinliği ile günümüzde sık kullanılmaya başlanmıştır. Hedefe yönelik monoklonal antikorların yan etkileri sitotoksik tedavilere göre daha hafif seviyede görülmektedir. İbrutinibin de ishal, bitkinlik, ateş, bulantı, kanama, sitopeniler, alerjik reaksiyonlar gibi yan etkileri görülmektedir. Kanama %50 den fazla vakada görülmüştür. Çoğunluğu peteşiyal kanamalar olmasına rağmen hayati tehdit eden kanamalara da yol açmaktadır. Bizde ibrutinibin kanamaya eğilimi olan hastalarda dikkatli kullanılmasını vurgulamak amacıyla, ibrutinib sonrası kanama gelişen vakamızı sunduk.

Ibrutinib, a novel therapeutic agent with increasing use as a highly effective treatment in Chronic lymphocytic leukemia and Mantle cell lymphoma, is associated with a lower incidence of side effects as compared to cytotoxic agents due to its mechanism of action involving targeted monoclonal- antibodies. However, ibrutinib may also cause side effects such as diarrhea, fatigue, fever, nausea, bleeding, cytopenia, or allergic reactions. Bleeding has been reported to occur in more than 50% of the patients, mostly in the form of petechial bleedings. However, life-threatening bleeding may also occur. Herein, we report a case with bleeding occurring after ibrutinib treatment in order to underscore the importance of careful use of this agent in patients with a predisposition for bleeding.

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