Ayşegül KURTOĞLU UĞUR, VOLKAN KARAKUŞ, ERDAL KURTOĞLU

Beta talasemi hastalarında serum paraoksonaz aktivitesi ile biyokimyasal parametreler arasındaki ilişki

Amaç: Beta talasemi (?-Thal) oksidan stessin arttığı, antioksidan kapasitenin azaldığı kronik hemolitik bir anemidir. Paraoksonaz antioksidan özelliği olan bir enzimdir. Bu çalışmamızda ?-Thal hastalarında paraoksonaz aktivitesini etkileyen belirteçleri araştırdık.Gereç ve Yöntem: 46 ?-Thal hastasında yapılan çalışmamızda serum paraoksonaz aktivitesi, tam kan sayımı ve açlık glukoz, BUN, kreatinin, sodyum, potasyum, klorür, kalsiyum, AST, ALT, LDH, albumin, globulin, ürik asit, indirekt bilurubin, direkt bilurubin, TSH, parathormon, ferritin, B12 düzeyleri ölçüldü.Bulgular: Serum paraoksonaz aktivitesi ile serum klorür (r=0.319, p

Objective: Beta thalassemia (?-Thal) is a chronic anemia in which while oxidants stress increases, antioxidant capacity decreases. Paroxanase is an enzyme having antioxidant properties. In this study we searched markers effecting paroxanase activity in ?-Thal patients.Materials and Methods: In this study we measured serum paroxanase activity, complete blood count, fasting glucose, BUN, creatinin, sodium, potassium, chloride, calcium, AST, ALT, LDH, albumin, globulin, uric acid, indirect bilirubin, direct bilirubin, TSH, parathyroid hormone, ferritin, and vitamin B12 in 46 ?-Thal patients.Results: We found that there is a significant correlation between serum paroxanase activity, serum chloride level, and serum TSH (r=0.319, p<0.05). There is no significant correlation between serum paroxanase activity and other parameters.Conclusion: Thyroid disorders and diseases effecting chloride levels do not effect serum paroxanase activity in ?-Thal patients.

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