Hasan KOÇ, MEHMET AKÖZ, Mehmet GÜRBİLEK, Mehmet AK, Mahmut AY, Ahmet GÜREL, Ümran ÇALIŞKAN

Hiperbilirubinemili yenidoğanlarda fototerapinin serbest radikaller üzerine etkisi

Amaç: İndirekt hiperbilirubinemili yenidoğanlarda fototerapinin serbest radikallere etkisinin araştırılması amaçlandı. Yöntem: Total bilirubinleri 15 mg/dl'nin üzerinde olan ve ortalama 44 saat fototerapi uygulanan 25 bebekte (fototerapi grubu) fototerapi öncesi ve sonrası bilirubin, hematokrit ve reaktif oksijen metabolitleri (ROM) düzeyi ölçüldü. Fototerapi uygulanmayan ve total bilirubin seviyeleri 10-15 mg/dl olan 25 bebek de (kontrol grubu) takibe alındı. Bulgular: Bebeklerin gebelik yaşları, ağırlıkları ve numune alındığı zamanki yaşam süreleri bakımından iki grup arasında önemli fark yoktu. Total bilirubin, direkt bilirubin, hematokrit ve ROM değerleri sırasıyla; fototerapi grubunda fototerapi öncesi 16.6± 1.2 mg/dl, 0.5± 0.1 mg/dl, % 56.8± 4.8, 322± 81 car unit. Fototerapi sonrası 8.1± 1.5 mg/dl, 0.4± 0.2 mg/dl, % 53.9± 5.4, 240± 64 car unit, kontrol grubunda ise 1. numunede 11.6± 2.6 mg/dl, 0.4± 0.1 mg/dl, % 55.0± 4.8, 307± 92 car unit, 2. numunede 11.8± 1.9 mg/dl, 0.4± 0.1 mg/dl, % 51.5± 4.8, 314± 80 car unit idi. Bilirubin değerleri yüksek olan ve fototerapi uygulanan grubun bilirubin ve ROM değerleri fototerapi sonrasında fototerapi öncesine göre anlamlı olarak düşüktü. Kontrol grubunda ise ilk ve ikinci ölçümler arasında fark yoktu. Sonuç: Fototerapi ile bilirubin değerleri düşerken ROM değerlerinde azalma olmaktadır.

Anahtar Kelimeler:

Reaktif oksijen türleri, Bilirubin, Oksijen, Sarılık, yenidoğan, Süt çocuğu, yenidoğan, hastalıklar, Süt çocuğu, yenidoğan, Hiperbilüribinemi, Hematokrit, Serbest radikaller, Fototerapi

The effect of phototheraphy on free radicals in newborns with hyperbilirubinemia

Objective: It was aimed to evaluate the effects of phototherapy on free oxygen radicals in newborns with indirect hyperbilirubinemia. Methods: Determination of bilirubin, hematocrit and reactive oxygen metabolites (ROM) levels were carried out before and after phototeraphy in 25 newborns (phototheraphy group) in whom total bilirubin was higher than 15 mg/dl. 25 newborn in whom total bilirubin was 10-15 mg/dl constituted the control group. Results: There was no statistical difference between gestational age, weight and life-span of the infants. The values of total bilirubin, direct bilirubin, hematocrit and reactive oxygen metabolites (ROMs) were 16.6± 1.2 mg/dl, 0.5± 0.1 mg/dl, 56.8± 4.8%, 322± 81 car unit before and 8.1± 1.5 mg/dl, 0.4± 0.2 mg/dl, 53.9± 5.4%, 240± 64 car unit after phototherapy in the phototherapy group, respectively. The values were 11.6± 2.6 mg/dl, 0.4± 0.1 mg/dl, 55.0± 4.8%, 307± 92 car unit and 11.8± 1.9 mg/dl, 0.4± 0.1 mg/dl, 51.5± 4.8 %, 314± 80 car unit in the control group at the first and the second samples, respectively. The levels of total bilirubin and ROMs before phototherapy were higher than those after phototherapy in the patient group. There was no statistical differences between values of hematocrit before and after phototherapy. Conclusion: We conclude that phototherapy decreases the levels of bilirubin as well as ROMs.

Keywords:

Reactive Oxygen Species, Bilirubin, Oxygen, Jaundice, Neonatal, Infant, Newborn, Diseases, Infant, Newborn, Hyperbilirubinemia, Hematocrit, Free Radicals, Phototherapy,

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ISSN: 2602-3741
Yayın Aralığı: Yılda 6 Sayı
Başlangıç: 1997
Yayıncı: SELÇUK ÜNİVERSİTESİ > TIP FAKÜLTESİ

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