Tülin ARAS, Özgen Pınar KIRATLI, Oktay SARI, Nilüfer GÜLER

Diferansiye tiroid karsinomlu hastalarda I-131 tedavisinin etkinliği

Amaç: Bu çalışmanın amacı diferansiye tiroid karsinomlu hastalarda cerrahi sonrası radyoaktif 1-131 tedavisinin etkinliğini değerlendirmektir. Yöntem: Hacettepe Üniversitesi Tıp Fakültesine başvuran diferansiye tiroid karsinomlu 95 hastada postoperatif tanısal tüm vücut 1-131 taraması yapıldı, ardından terapötik dozda radyoaktif iyot verildi. 95 hastanın 41'inde tiroid yatağında, 36'smda lenf nodlarında, 18'inde mediasten, akciğer ve/veya kemikte radyoiyot tutulumu vardı. Bulgular: 82 hastada (% 86) 100-200 mCi arasındaki ilk doz 1-131 ile başarılı ablasyon sağlanırken, 13 hastada ikinci veya üçüncü dozla ablasyon yapıldı. Sonuç: Diferansiye tiroid karsinomlu hastalarda total tiroidektominin ardından ablatif radyoaktif iyot tedavisi verilmesinin en uygun tedavi yöntemi olduğu sonucuna varıldı.

Anahtar Kelimeler:

Tiroid neoplazmları, Neoplazm metastazı, İyot radyoizotopları, Tiroidektomi, İyot

Effectiveness of I-131 treatment in patients with differentiated thyroid carcinoma

Objective: The purpose of this study was to evaluate the efficacy of postsurgical radioactive 1-131 therapy in patients with differentiated thyroid carcinoma. Methods: in ninety-five patients with differentiated thyroid carcinoma who were referred to Hacettepe University Medical Center, postoperative diagnostic total body 1-131 scan was done, subsequently patients received therapeutic radioactive iodine. Of 95 patients, 41 were with radioiodine uptake confined to the thyroid bed, 36 had distant uptake in the lymph nodes and 18 had distant metastases in the mediastinum, lung and/or bone. Results: A successful ablation was achieved in 82 patients (86%) with the first dose of 1-131 ranging from 100 to 200 mCi, while 13 patients had ablation with a second or third dose. Conclusion: Total thyroidectomy is associated with better ablation and is recommended when feasible, for differentiated thyroid cancer, followed by ablative 1-131 therapy.

Keywords:

Thyroid Neoplasms, Neoplasm Metastasis, Iodine Radioisotopes, Thyroidectomy, Iodine,

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