Mehmet Murat DİŞÇİ, Fatih Ersay DENİZ, Erol ÖKSÜZ, Özgür DEMİR

Akciğer Kanseri Beyin Metastazı Sonrası Serebral Enfarktüs

Kanser dünya üzerinde ölüm nedenleri arasında ikinci sırada yer almaktadır. Kanser hastalarında normal popülasyona oranla serebrovasküler hastalık gelişme riskinde artış izlenmektedir. Kanser ilişkili mekanizmalar içinde hiperkoagülasyon, tümör embolizmi ve tümör hücrelerinden salınan sitokinlerin (TNF ve İL) yarattığı vasküler endoteliyal doku hasarının yer aldığı ve hiperkogülopatinin önemli bir kısmından sorumlu olduğu görülmektedir. Bu olguda da akciğer kanseri beyin metastazı olan hastada serebral enfarktüs gelişmiştir. İntrakranial tümör embolisi nedeniyle oluşan serebral enfarktüs nadir görülen vakalardandır.

Anahtar Kelimeler:

Akciğer kanseri, serebral enfarktüs

Cerebral Infarction After Lung Cancer Brain Metastasis

Cancer is the second leading cause of death in the world. There is an increase in the risk of development of cerebrovascular disease in cancer patients compared to the normal population. Cancer-related mechanisms include hypercoagulation, tumor embolism, and vascular endothelial tissue damage caused by cytokines (TNF and IL) released from tumor cells, and are responsible for a significant portion of hypercogulopathyIn this case, cerebral infarction developed in the patient with lung cancer brain metastasis. Cerebral infarction due to intracranial tumor embolism is one of the rare cases

Keywords:

Lung cancer, cerebral infarction,

PDF

___

1. Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer. Medicine (Baltimore) 1985;64:16-35.
2. Dipasco PJ, Misra S, Koniaris LG, Moffat FL Jr. Thrombophilic state in cancer, part I: Biology, incidence, and risk factors. J Surg Oncol 2011;104(3):316-22.
3. Donati MB.Thrombosis and cancer: Trousseau syndrome revisited. Best Pract Res Clin Haematol 2009;22(1):3-8. 4. Chen PC, Muo CH, Lee YT, Yu YH, Sung FC. Lung cancer and incidence of stroke: A population-based cohort study. Stroke 2011;42(11):3034-9.
4. Kim SJ, Park JH, Lee MJ, et al. Clues to occult cancer in patients with ischemic stroke. PLoS One 2012;7:e44959.
5. Navi BB, DeAngelis LM, Segal AZ. Multifocal strokes as the presentation of occult lung cancer. J Neurooncol 2007;85:307-9.
6. Seok JM, Kim SG, Kim JW, et al. Coagulopathy and embolic signal in cancer patients with ischemic stroke. Ann Neurol 2010;68:213-9.
7. Kim SG, Hong JM, Kim HY, et al. Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. Stroke 2010;41:798-801.
8. Mai H, Xia J, Wu Y, et al. Clinical presentation and imaging characteristics of occult lung cancera ssociated ischemic stroke. J Clin Neurosci 2015;22:296-302.
9. Navi BB, Reichman JS, Berlin D, et al. Intracerebral and subarachnoid hemorrhage in patients with cancer. Neurology 2010;74:494-501. 10- Chen PC, Muo CH, Lee YT, Yu YH, Sung FC. Lung cancer and incidence of stroke: A population-based cohort study. Stroke 2011;42(11):3034-9.