DNA Dizilemenin Tarihsel Gelişimi

Nükleik asit dizi analizi, çok çeşitli araştırma uygulamalarının ayrılmaz bir bileşenidir. Son 50 yıl boyunca araştırıcıların çoğu DNA ve RNA moleküllerinin dizi analizlerini gerçekleştiren teknik ve teknolojilerin üretilmesi için çaba harcamıştır. Bu süreçte küçük boyutlu moleküllerin dizilenmesinden tüm genomun dizilenmesine kadar uzanan çok büyük gelişmeler olmuştur. Bu makalede belirtilen zaman aralığında DNA dizilemenin temelini oluşturan önemli gelişmeler, dizilemede kullanılan tekniklerin ve teknolojilerin ortaya çıkışı ve gelişmeleri açıklanmaktadır.

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