Nurşen SARI, Elif LOĞOĞLU, SEZA ARSLAN, İffet ŞAKIYAN

Antibacterial activites of some new amino acid-schiff bases

Indol-3-karboksaldehit ve DL-glycine, DL-alanine ve DL-valin'nin kondenzasyon yolu ile bazı yeni (N-indolidene-DL-glycine, N-indolidene-DL-alanine and N-indolidene-DL-valine) amino acid-Schiff bazları sentezlenerek yapılan element analizi, IR, UV-Vis, $^1H-NMR$ ve $^1H-NMR$ spektroskopi ile aydınlatıldı. Amino acid- Schiff bazlarının dört farklı mikroorganizmalara karşı antimikrobial aktiviteleri ölçüldü.

Bazı yeni amino asit-schiff bazlarının antimikrobiyal aktiviteleri

Some new (N-indolidene-DL-glycine, N-indolidene-DL-alanine and N-indolidene-DL-valine) amino acid-Schiff bases were prepared by the condensation of indole-3-carboxaldehyde and DL-glycine, DL-alanine and DL-valine and characterized by elemental analysis, IR, UV-Vis, $^1H-NMR$ spectroscopy and $^1H-NMR$ spectroscopy. Antimicrobial activities of the amino acid-Schiff bases have been tested against four different microorganisms.

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1. Lau, K. Y., Mayr, A., Cheung, K. K. "Synhesis of transition metal isocyanide complexes containig hydrogen bonding sites in peripheral locations", Inorg. Chim. Acta, 285: 223-232, (1999).
2. Shawali, A. S., Harb, N.M.S., Badahdah, K. O. "A study of tautomerism in diazonium coupling products of 4- hyroxycoumrin", J. Heterocylylic Chem., 22: 1397-1403 (1985).
3. Opletalová, V., Hartl, J., Patel, A., Palát, A. and Buchta, V. "Ring substituted 3- phenyl-1- (2-pyrazinyl)-2- propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents", Farmaco, 57: 135-144 (2002).
4. Biava, M., Fioravanti, R., Porretta, G. C., Sleite, G., Deidda, D., Lampis, G. and Pompei, R. "Antimycobacterial activity of new otho-, meta- and para-toluidine derivatives", Farmaco, 54: 721-727 (2002).
5. "The Reader's digest great encyclopaedic dictionary", Three volume, A-L, 71.
6. Perrin, D.D., Armarego, W. L. F and Perrin, D. D. Purification of Laboratory Chemicals, Pergamon Press.Second Edition, Oxford, 66-72 (1980).
7. Silverstein, R.M., Bassler, C. G., Morrill, T. C., "Spectrometric identification of organic compounds" 3.Edition, Wiley and Sons USA-1974, 247, 254-189 (1974).
8. Boraei, A. A. A. " Synthesis and characterization of mixed- ligand complexes of Co(II), Ni(II), and Cu(II) with some triazoles and amino acids", Synth. React. Inorg. Met.-Org. Chem., 32: 291-304 (2002).
9. Sarı, N. and Şakıyan, İ. "Synthesis and characterization of new Mn(III) complexes of Schiff Bases derived from some amino acids and indole-3-carboxaldehyde", J. Inst. Science and Tech., Gazi Uni., 15: 339-344 (2002).
10.Sharma, P. K. and Dubey, S. N. "Synthesis and structural studies of iron(II) complexes with N-salicylideneand N-(2-hydroxy-1-naphthylidene)amino acids", Ind. J. Chem., 33A: 1113-1115 (1994).
11. Jayabalakrishnan, C. and Natarajan, K. "Ruthenium(II) carbonyl complexes with tridentate Schiff bases and their antibacterial activity", Transition Met. Chem., 27: 75-79 (2002).
12. Raman, N., Kulandaisamy, A., Shunmugasundaram, A., and Jeyasubramanian, K."Synthesis, spectral, redox and antimicrobial activities of Schiff base complexes derived from 1-phenyl-2,3-dimethyl-4- aminopyrazol-5-one and acetoacetanilide", Transition Met. Chem., 26: 131-135 (2001).
13. Tso W-W. and Fung W-P., "Correlation between the antibacterial activity and alkali metal ion transport efficiency of crown ether", Inorg. Chim. Acta, 55: 129-134 (1981).