Submandibular bezin castleman hastalığı

Castleman hastalığı (CH) veya anjiyofoliküler lenf nodu hiperplazisi lenf nodu hiperplazisine neden olan, nadir, benign, etyolojisi bilinmeyen bir hastalıktır. Bu hastalık, hekimlerin çoğu için teşhis ve tedavi yönünden bir ikileme neden olmaktadır. Hastalığın kesin tanısı için doku biyopsisi gereklidir. CH, submandibular bezi nadiren tutar. Boyun bölgesinde yerleşen solid formlarının tedavisi cerrahi eksizyondur. Bu makalede, 42 yaşında bir kadın hastada submandibular bez yerleşimli CH olgusu literatür gözden geçirilerek sunulmuştur. (Gazi Med J 2011; 22: 97-9)

Castleman’s disease of submandibular gland

Castleman’s disease (CD), or angiofollicular lymph node hyperplasia, is a rare, benign disease of unknown etiology giving rise to lymph node hyperplasia. This disease creates both diagnostic and therapeutic dilemmas for most physicians.Tissue biopsy is necessary for a definitive diagnosis. CD of the submandibular gland occurs very rarely. Surgery is the treatment of choice for the solitary form in the neck region. We present a 42 year-old woman with CD of submandibulargland together with the review of the literature. (Gazi Med J 2011; 22: 97-9)

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  • 1. Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case 4001. N Engl J Med 1954; 250: 1001-5.
  • 2. Gangopadhyay K, Mahasin ZZ, Kfoury H. Castleman disease (giant lymph node hyperplasia). Arch Otolaryngol Head Neck Surg 1997; 123: 1137-9.
  • 3. Flendring JA. Benign giant lymphoma: Clinicopathologic correlation study. In: Clark RL, Cumley RW, editors. The year book of cancer, Chicago: Year Book Medical Publishers 1970; P: 296-9.
  • 4. Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma cell types of giant lymp node hyperplasia of the mediastinum and other locations. Cancer 1972; 29: 670-83.
  • 5. Bowne WB, Lewis JJ, Filippa DA, Niesvizky R, Brooks AD, Burt ME, et al. The management of unicentric and multicentric Castleman’s disease. Cancer 1999; 85: 706-17.
  • 6. Shahidi H, Myers JL, Kvale PA. Castleman’s disease. Mayo Clin Proc 1995; 70: 969-77.
  • 7. Chen CC, Jiang RS, Chou G, Wang CP. Castleman’s disease of the neck. J Chin Med Assoc 2007; 70: 556-8.
  • 8. Sanchez-Cuellar A, de Pedro M, Martin-Granizo R, Berguer A. Castleman disease (giant lymph node hyperplasia) in the maxillofacial region: a report of 3 cases. J Oral Maxillofac Surg 2001; 59: 228-31.
  • 9. Somdas MA, Ketenci I, Bicer S, Senturk M, Guney E. Castleman’s Disease as an unusual neck mass: Case report. Ann Otol Rhinol Laryngol 2004; 113: 459-61.
  • 10. Osma U, Cureoglu S, Yaldiz M, Topcu I. Castleman’s Disease (giant lymp node hyperplasia) of the neck: A case report. Eur Arch Otorhinolaryngol 2001; 258: 42-4.
  • 11. Acar A, Eryılmaz A, Akmansu H ve ark. Boyunda izole Castleman Hastalığı. Kulak Burun Boğaz ve Baş Boyun Cerrahisi Dergisi 2001; 9: 59-61.
  • 12. Dursun E, Cıncık H, Hahoğlu A ve ark. Boyun yerleşimli hyalin vasküler tip Castleman Hastalığı: İki olgu. KBB Forum 2007; 6: 37-40.
  • 13. McCarty MJ, Vukelja SJ, Banks PM, Weiss RB. Angiofollicular lymph node hyperplasia (Castleman’s disease). Cancer Treat Rev 1995; 21: 291-310.
  • 14. Schnitzer B. Reactive lymphoid hyperplasias. In: Jaffe ES. Surgical pathology of the lymph nodes and relate organs. Philadelphia, PA: WB Saunders Company 1995, p: 107-111.
  • 15. Yi AY, deTar M, Becker TS, Rice DH. Giant lymph node hyperplasia of the head and neck (Castleman’s disease): a report of five cases. Otolaryngol Head Neck Surg 1995; 113: 462-6.
  • 16. Tan TY, Pang KP, Goh HK, Teo EL, Abhilash B, Walford N. Castleman’s dis-ease of the neck: a description of four cases on contrast-enhanced CT. Br J Radiol 2004; 77: 253-6.
  • 17. Casper C. The aetiology and management of Castleman’s disease at 50 years: translating pathophysiology to patient care. Br J Haematol 2005; 129: 3-17.
  • 18. Sanz C, Sierra J, Cobarro J, Avellaneda R, Montserrat E, Rozman C. An unusual case of Castleman’s disease restricted to the neck. ORL J Otorhinolaryngol Relat Spec 1992; 54: 331-3.
Gazi Medical Journal-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Gazi Üniversitesi Tıp Fakültesi