M. Akif ÖZTÜRK, Sedat KİRAZ, Serafettin KİRAZLI, Meral ÇALGÜNERİ, İhsan ERTENLİ, A. Mesut ONAT, İbrahim C. HAZNEDAROĞLU

Soluble P-selectin in primary Sjögren's syndrome

Amaç: Sjögren sendromu (SS) tükrük, lakriraal ve diğer ckzokrin bezlerin fokal lenfositik infıltrasyonu ile karakterizedir. P-selektin inflamatuvar hücrelerin inflamasyon alanına yerleşmesinde kritik roller oynayan bir hücre adezyon molekülüdür. P-selektin kan dolaşımında çözünür bir formda da bulunabilir. Çözünür p-selektin aktif bir moleküldür ve lökosit-endotel etkileşimini önleyerek anti- inflamatuvar fonksiyonlar görebilir. Bu çalışmamızda primer SS hastalarda çözünür p- selektin düzeylerini inceledik. Metodlar: Çalışmaya primer SS tanısı almış 8 hasta [7 kadın, 1 erkek; ortalama yaş 44.88 yıl (35-58)] ve 10 sağlıklı kontrol [6 kadın, 4 erkek; ortalama yaş 32.3 yıl (19- 44)] dahil edildi. Çözünür p-selektin düzeyleri kantitatif sandviç imünassay yöntemi ile ölçüldü. Sonuçlar: Ortalama çözünür p-selektin düzeyleri SS hastalan ve sağlıklı kontroller için sırasıyla 168±94.7 ng/mL ve 50.7±29.0 ng/mL idi. Çözünür p-selektin düzeyleri SS hastalarında kontrollere göre anlamlı olarak daha yüksek idi (pO.01). Sonuç: Bu pilot çalışmada gördüğümüz ön bilgiler çözünür p-selekti-nin SS patobiyolojisinde roJ oynayabileceğini düşündürmektedir.

Primer Sjögren sendromunda çözünür P-selektin düzeyleri

Purpose: Sjögren's syndrome (SS) is characterized by focal lymphocytic infiltration of the salivary, lacrimal, and other exocrine glands. P-Scle-ctin is a cell adhesion molecule that plays critical roles in the homing of the inflammatory cells to the site of inflammation. A soluble form of P-selectin can also be found in the plasma as a circulating protein. The sP-Sclcctin is also active and could play anti-inflammatory functions by preventing leukocytc-cndothelium interactions. In this study, we investigated serum levels of sP-Selectin in patients with primary SS. Methods: Eight patients with primary SS (7 female, 1 male; mean age 44.88 years (35-58)) and 10 healthy subjects (6 female, 4 male; mean age 32.3 years (19 to 44)) were enrolled in this study. sP-Selectin levels were measured using the quantitative sandwich immunoassay technique. Results: The mean sP-Selectin levels were 168±94.7 ng/mL and 50.7±29.0 ng/mL for patients with SS and for healthy controls, respectively. sP-Selectin levels were significantly higher in SS patients than in the healthy controls (pO.01). Conclusion: The preliminary data from this pilot study suggested that sP-Selectin might have some place in the pathobiology of SS.

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