Coexisting intrathyroidal parathyroid adenoma and micropapillary carcinoma of the thyroid
Paratiroidler nadiren ektopik lokalizasyonlarda bulunabilir. Ektopik yerleşimli paratiroidlerin büyük çoğunluğu ön mediastende timus içerisinde, arka mediastende, tiroid içerisinde ve nadiren de karotis kılıfında bulunurlar. Diğer ektopik paratiroid görülen yerler perikard, vagus siniri ve mandibula köşesindeki yumuşak dokudur. Paratiroid adenomları ektopik yerleşimli bezlerden de gelişebilir. Bu ektopik yerleşimli paratiroid adenomları primer hiperparatiroidizme de neden olabilir. İntratiroidal paratiroid adenomu ile birlikte tiroid papiller karsinomu görülmesi oldukça nadir bir durumdur. Bu makalede 76 yaşındaki bir kadm hastada mikropapiler tiroid kanseri ile senkron görülen bir intratiroidal paratiroid adenomu olgusu sunulmaktadır.
Tiroid papiller karsinomu ile birlikte görülen bir intratiroidal paratiroid adenomu
Parathyroid glands are occasionally found in an ectopic location. The vast majority of ectopic parathyroid glands are found within the thymus, in the anterior mediastinum, followed by the posterior mediastinum, thyroid and, rarely, the carotid sheath. Other rare sites of ectopy include the pericardium, vagus nerve or the soft tissue adjacent to the angle of the jaw. Parathyroid adenomas can occur in any site containing ectopic parathyroid tissue. Ectopic parathyroid adenomas may also be the cause of primary hyperparathyroidism. The concomitant existence of intrat-hyroidal parathyroid adenoma and papillary carcinoma of the thyroid is exceedingly rare. Here we report a case of intrathyroidal parathyroid adenoma associated with a synchronous micropapillary carcinoma in a 76-year-old female patient.
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- 1. Summers GW. Parathyroid update: a review of 220 cases. Ear Nose Throat J. 1996; 75: 434-9.
- 2. Zeze f, Itoh H, Ohsato K, Hyperplasia and adenoma of the ectopic parathyroid gland, Nippon Rinsho. 1995; 53: 920-4.
- 3. Schweizer I, Bleisch JA, Gemsenjager E. Primary Hyperthyroidism 1996. Schweiz Med Wochenschr. 1997; 127: 243-53.
- 4. Richards ML, Bondeson AG, Thompson NW: Mediastinal parathyroid adenomas and carcinomas. In General Thoracic Surgery. Volume 2. 5th edition. Edited by: Shields TW, LoCicero III J, Ponn RB.Philadelphia: Lippincot Williams and Willkins; 2000: 2383-2390.
- 5. Krause UC, Friedrich JH, Olbricht T, Metz K. Association of primary hyperparathyroidism and non-medullary thyroid cancer. Eur J Surg. 1996; 162: 685-9.
- 6. Kösem M, Algun E, Kotan C, Harman M, Öztürk M. Coexistent thyroid pathologies and high rate of papillary cancer in patients with primary hyperparathyroidism: controversies about minimal invasive parathyroid surgery. Acta Chir Belg. 2004; 104: 568-71.
- 7. Rodriquez JM, Tezelman S, Siperstein AE, Duh QY, Higgins C, Morita E, Dowd CF, Clark OH. Localization procedures in patients with persistent or recurrent hyperparathyroidism. Arch Surg. 1994; 129:870-5.
- 8. Proye C, Bizard JP, Carnaille B, Quievreux JL. Hyperparathyroidism and intrathyroid parathyroid gland. 43 cases. Ann Chir. 1994; 48:501-6.
- 9. Feliciano DV. Parathyroid pathology in an intrathyroidal position. Am J Surg. 1992; 164: 496-500.
- 10. de la Cruz Vigo F, Ortega G, Gonzalez S, Martinez JI, Cruz Leiva J, Galvez R, Menendez JM, Yuste P. Pathologic intrathyroidal parathyroid glands. Int Surg. 1997; 82: 87-90.
- 11. Bernd HW, Horny HP. Unusually close association of ectopic intrathyroidal parathyroid gland and papillary microcarcinoma of the thyroid. Histopathology. 2004; 44: 300-1.
- 12. Boi F, Cau R, Piga M, Serra A, Loy M, Lai ML, Mariotti S. 99mTc-SestaMIBI scintigraphy of thyroid gland in a patient with primary hyperparathyroidism: unusual features due to coexistence of a thyroid papillary carcinoma. Clin Endocrinol (Oxf). 2003; 59: 823-4.