Murat YILMAZ, Sevsen KULAKSİZOĞLU, Turgay ARINSOY, Ülver DERİCİ, Şükrü SİNDEL, Fatma Ayerden EBİNÇ

Lipid peroxıdatıon and the antıoxıdant capacıty of dıalysıs patıents: the effects of a single hemodialysis session with different dialysis membranes

Amaç: Bu çalışmanın amacı diyaliz hastalarının lipid peroksidasyon ve antioksidan savunma kapasitelerini tespit etmek ve değişik tipteki diyaliz membranlarının bu parametreler üzerine etkilerini göstermektir. Metot: Çalışmaya 54 diyaliz hastası ve kontrol grubu olarak 30 sağlıklı birey alındı. 54 diyaliz hastasının 10’u periton diyalizi, 44’ü hemodiyaliz hastasından oluşmaktaydı. Hemodiyaliz hastaları polikarbonat (n=10) ya da hemophan membran (n=34) kullanılarak hemodiyalize alınmaktaydı. Polikarbonat membran kullanılan grupta, sonraki diyaliz seansında membranlar vitamin-E kaplı dializer ile değiştirildi. Antioksidan savunma kapasitesi ve lipid peroksidasyonunu belirlemek için total antioksidan durumu ve malondialdehid seviyeleri diyaliz öncesi ve diyaliz sonrasında çalışıldı. Sonuçlar: Kontrol grubu ile karşılaştırıldığında tüm diyaliz hastalarında plazma total antioksidan seviyesi daha düşük (1.51±0.2 mmol/L ‘ye karşı 1.75±0.20 mmol/L p

Diyaliz hastalarında lipid peroksidasyon ve antioksidan kapasitesi: farklı diyaliz membranları ile yapılan tek bir diyaliz seansının etkileri

Objective: To estimate lipid peroxidation and the antioxidant defense capacity of dialysis patients and the effects of different types of dialysis membranes on these parameters. Methods: Fifty-four dialysis patients and 30 healthy controls were included in this study. Ten of the dialysis patients were on continuous ambulatory peritoneal dialysis treatment and the rest were on hemodialysis with either polycarbonate membrane (n=10) or hemophan membrane (n=34). Polycarbonate membranes were switched with a vitamin E-coated dialyzer in the subsequent dialysis session. Total antioxidant status and malondialdehyde levels were studied to determine the antioxidant defense capacity and lipid peroxidation, respectively, before and after the dialysis session. Results: Plasma total antioxidant status levels were lower (1.51±0.2 mmol/l vs. 1.75±0.20 mmol/l p

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