İpek Işık GÖNÜL, Zafer TÜRKYILMAZ, Ömür ATAOĞLU, Cem SEZER, Nüket ÜZÜM, Bilge KARABULUT

Large cell calcifying sertoli cell tumor of the testis: A case report

Testisin büyük hücreli kalsifıkasyon gösteren sertoli hücreli tümörü (TBHKST) nadir görülen bir sertoli hücreli tümör varyantıdır ve tüm testis tümörlerinin %1'inden azını oluşturur. Genellikle benign karakterde, multifokal ve bilateral görülen tümörün nadir olmakla birlikte malign formu da mevcuttur. Çoğunlukla genç erkeklerde, tesliste kitle ile farkedilen tümör, Carney sendromu (kalp, deri, oral kavite ve meme yerleşimli olabilen migzomalar, adrenokortikal hiperplazi, hipofızer adenom, deride pigmentasyonlar) ya da Peutz-Jeghers sendromu gibi kalıtsal endokrin bozukluklara eşlik edebilir. Burada klinik ve histopatolojik tam güçlüğüne neden olabilen testisin büyük hücreli kalsifıkasyon gösteren sertoli hücreli tümör olgusu, sınırlı sayıdaki olgunun artması, klinik ve patolojik bulguların tartışılması amacıyla 2 yıllık klinik takip sonrası özellikleri ile birlikte sunulmuştur.

Testisin büyük hücreli kalsifikasyon gösteren sertoli hücreli tümörü: Olgu sunumu

Large cell calcifying sertoli cell tumor of the testis is an uncommon variant of sertoli cell tumors, accounting for less than 1% of all testicular neoplasms. Although it is usually benign and multifocal, malignant forms also exist but are exceptional. The tumor is predominantly associated with hereditary endocrine anomalies like Carney complex (myxomas of the heart, skin, oral cavity and breast, adrenocortical hyperplasia, pituitary adenomas, lentigines of the skin and other anomalies) and Peutz-Jeghers syndrome. A young child with a testicular mass that proved to be a large cell calcifying sertoli cell tumor is reported here. We discuss the pathological and clinical findings in terms of their correlation after a 2-year follow-up of the patient.

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1. Ulbright TM, Roth LM. Testicular and Paratesticular Neoplasms. In: Stephen S. Sternberg, (ed): Diagnostic Surgical Pathology. 2nd ed. Philadelphia: Lippincott- Raven; 1994; 1924-1925.
2. Proppe KH, Scully RE. Large cell calcifying Sertoli cell tumor of the testis. Am J Clin Pathol 1980; 74: 607-619.
3. Young RH, Talerman A. Testicular tumors other than germ cell tumors. Semin Diagn Pathol 1987; 2: 528-530.
4. Tanaka Y, Sano K, Ijiri R, Tachibana K, Kato K, Terashima K. A case of large cell calcifying Sertoli cell tumor in a child with a history of nasal myxoid tumor in infancy. Pathol Intern 1999; 49: 471-476.
5. White MD, Loughlin MW, Kallakury BVS, Ross JS, Mandell J. Bilateral large cell calcifying Sertoli cell tumor of the testis in a 7-year-old boy. J Urol 1997; 158: 1547- 1548.
6. Tanaka Y, Yamaguchi M, Ijiri R, Kondo I. Malignant large cell calcifying Sertoli cell tumor with endocrine overactivity. J Urol 1999; 161: 1575.
7. Cano-Valdez AM, Chanona-Vilchis J, Dominguez- Malagon H. Large cell calcifying Sertoli cell tumor of the testis: A clinicopathological, immunohistochemical and ultrastructural study of two cases. Ultrastr Pathology 1999; 23: 259-265.
8. Carney JA. Carney complex: The complex of myxomas, spotty pigmentation, endocrine overactivity and schwannomas. Semin Dermatol 1995; 14: 90-98.
9. Nogales FF, Andujar M, Zuluaga A, Garcia-Puche JL. Malignant large cell calcifying Sertoli cell tumor of the testis. J Urol 1995; 25(suppl 1): 236-237.
10. Kratzer SS, Ulbright TM, Talerman A, Srigley JR, Roth LM, Wahle GR, Moussa M, Stephens JK, Millos A, Young RH. Large cell calcifying Sertoli cell tumor of the testis. Contrasting features of six malignant and six benign tumors and a review of the literature. Am J Surg Pathol 1997; 21: 1271-1280.