Mehmet OĞUZ, B.Bülent MENTEŞ, Bahadır EGE, Osman YÜKSEL, Hasan BOSTANCI, Aytuğ ÜNER, Diclehan ÜNSAL

Kolorektal kanserlerin tedavi sonuçları: Tek merkezli, 200 vakalı seri

Amaç: Bu çalışmada tek merkezli bir seride kolorektal kanserli hastaların tedavi sonuçları, sağkalım oranları ve sağkalımla ilişkili faktörlerin belirlenmesi amaçlanmaktadır. Hastalar ve Yöntemler: Şubat 2000-Ekim 2005 tarihleri arasında elektif koşullarda ameliyat edilen ve tamamı histopatolojik olarak teyid edilmiş adenokanser vakaları olan 200 kolorektal kanserli hasta çalışmaya alındı. Hastalarda demografik özellikler, ek hastalıklar, postoperatif komplikasyonlar ve sağkalım oranları literatür verileriyle de kıyaslanarak değerlendirildi. Bulgular: Küratif cerrahi girişim kolon kanserli hastaların %94.6’sına, rektum kanserli hastaların %94.2’sine yapıldı. 85 hastada (%42.5) ek hastalıklar mevcuttu. Yara yeri infeksiyonu %5, anastomoz kaçağı oranı ise %1.5 oranında görüldü. 5 yıllık sağkalım oranları kolon kanserli hastalarda evre I, II, III ve IV için sırasıyla %96.3, %87.9, %78.9 ve %32 olarak bulunurken, rektum kanserli hastalarda evre I, II, III ve IV için sırasıyla %93.3, %96.4, %82.6 ve %33.3 olarak bulundu. Tartışma: Hastaların beslenme durumlarının düzeltilmesi, yara infeksiyonlarının azlığı, anastomoz kaçağı oranlarının düşük olması, kan transfüzyonlarının preoperatif dönemde yapılması, riskli hastalara venöz tromboemboli proflaksisi yapılması gibi unsurlar postoperatif komplikasyonların daha az olmasına ve peroperatif mortalitenin azlığına katkı sağlayarak sağkalım oranlarını iyileştirebilmektedir.

The result of colorectal cancer treatment: an institutional series of 200 cases

Purpose: To determine the institutional results of treatment of colorectal cancer, including survival rates and factors related to survival. Patients and Methods: In this study, 200 colorectal cancer patients who were operated on electively between February 2000 and October 2005 were analyzed. Demographic features, comorbid factors, postoperative complications, and survival rates were evaluated. Results: Curative surgery was performed in 94.6% and 94.2% of colon and rectal cancer patients, respectively. Comorbid diseases were present in 85 patients (42.5%). Wound infection and anastomotic leakage were seen in 3% and 1.5% of the patients, respectively. Five-year survival rates were 96.3%, 87.9%, 78.9%, and 32% for colon cancer patients with stage I, II, III, and IV, respectively. The survival rates for rectal cancer were 93.3%, 96.4%, 82.6%, and 33.3% for stage I, II, III, and IV, respectively. Conclusion: Factors such as supporting the nutritional status of patients, blood transfusion in the preoperative period, thromboembolism prophylaxis in high risk patients, low rates of wound infection, and anastomotic leakage may lead to reduced rates of postoperative complications and peroperative mortality, and improve overall survival.

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