Castleman’s disease in the neck and parotid region: A report of two cases-

Castleman hastalığı anjiyofoliküler lenf nodu veya dev lenf nodu hiperplazisi olarak da adlandırılmaktadır. Çoğunlukla yetişkinlerde görülür ve erkek-kadın oranı eşittir. Histolojik olarak hiyalen vaskuler tip ve plazma hücreli tip olmak üzere iki ana tipi mevcuttur. Klinik olarak unisentrik veya multisentrik formları bulunmaktadır. Bu çalışmada boyun bölgesinde ve parotis bezinde izole kitle şikayeti ile başvuran, yapılan cerrahi sonrası histopatolojik olarak hiyalen vaskuler tip Castleman hastalığı tanısı alan iki olgu sunulmuştur. (Gazi Med J 2012; 23: 69-72)

Boyun ve parotis bezi yerleşimli castleman hastalığı: İki olgu sunumu

Castleman’s disease is also known as angiofollicular lymph node or giant lymph node hyperplasia. It occurs most commonly in adults, equally in men and women. There are two clinical presentations as unicentric and multicentric forms. The two main histological types described are the hyaline vascular and the plasma cellular types. In this study, two cases of unicentric, hyaline vascular Castleman’s disease with parotid gland and neck involvement which were surgically excised and histopathologically diagnosed are presented. (Gazi Med J 2012; 23: 69-72)

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  • 1. Castleman B, Towne VW. Case record of the Massachusetts General Hospital: Case No. 40231. N Engl J Med 1954; 250: 1001-5.
  • 2. Park JH, Lee SW, Koh YW. Castleman disease of the parotid gland in childhood: An unusual entity. Auris Nasus Larynx 2008; 35: 451-4. [CossRef]
  • 3. Samadi DS, Hockstein NG, Tom LW. Pediatric intraparotid Castleman’s disease. Ann Otol Rhinol Laryngol 2003; 112: 813-6.
  • 4. Mohan H, Bal A, Tahlan A. Images in pathology. Castleman’s disease of the parotid. J Postgrad Med 2003; 49: 348-9.
  • 5. Zhong LP, Wang LZ, Ji T, Hu YH, Hu YJ, Ye WM, et al. Clinical analysis of Castleman disease (hyaline vascular type) in parotid and neck region. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 432-40. [CossRef]
  • 6. Nguyen DT, Diamond LW, Hansmann ML, Alavaikko MJ, Schröder H, Fellbaum C, et al. Castleman’s disease. Differences in folliculer dendritic network in the hyaline vascular and plasma cell variants. Histopathology 1994; 24: 437-43. [CossRef]
  • 7. Yi AY, deTar M, Becker TS, Rice DH. Giant lymph node hyperplasia of the head and neck (Castleman’s disease): a report of five cases. Otolaryngol Head Neck Surg 1995; 113: 462-6. [CossRef]
  • 8. Herrada J. Cabanillas F, Rice L, Manning J, Pugh W. The clinical behavior of localized and multicentric Castleman Disease. Ann Intern Med 1998; 1137-9.
  • 9. Gangopadhyay K, Mahasin ZZ, Kfoury H. Castleman disease (giant lymph node hyperplasia). Arch Otolaryngol Head Neck Surg 1997; 123: 1137-9.
  • 10. Parez N, Bader-Meunier B, Roy CC, Dommerques JP. Paediatric Castleman disease: report of seven cases and review of the literature. Eur J Pediatr 1999; 158: 631-7. [CossRef]
  • 11. Casper C. The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematl 2005; 129: 3-17. [CossRef]
  • 12. Keller A, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymp node hyperplasia of the mediastinum and other locations. Cancer 1972; 29: 670-83. [CossRef]
  • 13. Parravicini C, Corbellino M, Paulli M, Magrini U, Lazzarino M, Moore PS, et al. Dysregulated interleukin 6 expression produces a syndrome resembling Castleman disease. Ann J Pathol 1997; 151: 1517-22.
  • 14. Chen KT. Multicentric Castleman’s disease and Kaposi’s sarcoma. Am J Surg Pathol 1984; 8: 287-93. [CossRef]
  • 15. Petreson B,Frizzera G. Multicentric Castleman’s disease. Semin Oncol 1993; 20: 636-47.
  • 16. Oksenhendler E, Boulanger E, Galicier L, Du MQ, Dupin N, Diss TC, et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non- Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood 2002; 99: 2331-6. [CossRef]
  • 17. Salisbury JR. Castleman’s disease in childhood and adolescence: report of a case and review of literature. Pediatr Pathol 1990; 10: 609-15. [CossRef]
  • 18. Mallik MK, Kapila K, Das DK, Haji BE, Anim JT. Cytomorphology of hyaline vascular Castleman disease: A diagnostic challenge. Cytopathology 2007; 18: 168-74.
  • 19. Chronowski GM, Ha CS, Wilder RB, Cabanillas F, Manning J, Cox JD. Treatment of unicentric and multicentric Castleman disease and the role or radioterapy. Cancer 2001; 92: 670-6. [CossRef]
  • 20. Dham A, Peterson B. Castleman disease. Curr Opin Hematol 2007; 14: 354-9. [CossRef]
Gazi Medical Journal-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Gazi Üniversitesi Tıp Fakültesi
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