Mine ÇALIŞKAN, Kutlay KARAMAN, Tuğçin Bora POLAT, Cihan DURAN, Feyzullah ÇETİNKAYA

Assessment of hıppocampal volumes in infants with a history of bacterial meningitis

Amaç: Merkezi sinir sistemi enfeksiyonu hikayesi bulunan epilepsi gelişmiş hastalarda temporal bölge değerlendirilmesi ve hipokampuslarmm hacimsel incelenmesi önerilmektedir. Bu çalışmada yakın dönemde menenjit tedavisi görmüş süt çocuklarının hipokampus hacimleri kantitatif olarak değerlendirildi. Gereç ye Yöntem : Menenjit tanısı konulan 2 yas altı 26 olgu çalışmaya alındı. Aynı yas grubu 12 kontrol olgusu hipokampus hacimlerinin kıyaslanması açısından çalışmaya dahil edildi. Bulgular: Yirmialtı olgunun onunda hipokampial küçülme saptandı. Bunlardan altısı çift taraflı, dördü tek taraflı idi. Enfeksiyon döneminde konvülziyon geçiren 12 olgunun altısında çift taraflı üçünde tek taraflı küçülme gözlendi. Sonuç: Hipokampal etkilenme özellikle çocukluk döneminde menenjit geçirmiş olgularda enfeksiyon döneminde gelişen komplike nörolojik sorunlarla ve de sıklıkla tedaviye dirençli konvülziyonlarla yakından ilişkilidir. Bu hastaların hipokampal değerlendirmesi etkilenmenin sıklıkla her iki hipokampusuda içermesi ve de sıklıkla asimetrik olmayışı ile kantitatif yöntemlerle yapılmalıdır.

Bakteriyel menenjit geçirmiş süt çocuklarında hipokampal hacimlerin değerlendirilmesi

Purpose: To assess the hippocampal damage that occurs soon after a meningitic episode with a view to obtaining data that might contribute to an understanding of whether such changes were likely to be caused by the meningitis. Materials and Methods: Children under the age of 2 years were enroiled in the study. Hippocampal volumes and T2 relaxation times were measured. The results were compared with those of 12 control subjects undergoing magnetic resonance imaging of the brain for reasons other than epilepsy. I Results: Ten of the 26 study infants had hippocampal reduction; six of them had bilateral and four had unilateral hippocampal reduction. Six-of the study subjects that had experienced convulsions during the acute stage of meningitis had hippocampal reduction. Conclusion: There is a high prevalence of hippocampal damage in infants with a recent history of bacterial meningitis and this has a strong correlation with convulsions during meningitic episodes. Assessment of hippocampal atrophy in patients with a history of meningitis should warrant a volumetric analysis of the hippocampi with volume correction to identify possible bilateral volume loss.

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