Paratüberkülozisli Bir Koyunda Serum Biyokimyası ve Patolojik Bulgular

Hastalığın materyalini iştahsızlık, yatalaklık ve zayıflama şikayetleri olan 2 yaşındaki İvesi ırkı bir koyun oluşturdu. Klinik muayenede vücut ısısı normal olmasına karşın, solunum ve kalp frekansında artış belirlendi. Gaita muayenesinde herhangi bir paraziter etken görülmedi. Serumda total protein, albumin, kalsiyum ve magnezyum düzeyleri düşük olarak tespit edildi. Hastalığın kesin tanısı için nekropsi yapıldı ve laboratuvar incelemeleri sonucunda hastalık paratuberkülozis olarak belirlendi. Sonuç olarak, klinik ve patolojik muayeneler yanında serumda biyokimyasal incelemelerin de koyunlarda paratuberkülozisin klinik teşhisinde yardımcı olabileceği kanısına varıldı.

Serum Biochemistry and Pathological Findings in A Sheep with Paratubeculosis

The case was diagnosed in a 2 years old Ivesi sheep complain with anorexia, recumbency and thinning. In clinical examination; body temperature is normal, but respiration and heart rate were increased. It wasn’t determined any parasitic disease in the fecal examination. The total protein, albumine, calcium, and magnesium levels was decreased in the serum. For the definitive diagnosis, the sick animal was necropsied, and the sheep disease was identified as paratuberculosis in the laboratory examination. In conclusion, serum biochemical examination apply with clinical examination would be usefull in the clinical diagnosis of paratuberculosis in sheep.

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William PS. Johne’s disease in sheep and goats. http://www.ohioline.osu.edu/vmefact/0003.html/ 18.03.2010.
Williams ES, Snyder SP, Martin KL. Experimental infection of some North American wild ruminants and domestic sheeps with Mycobacterium paratuberculosis: clinical and bacteriological findings. J Wildlife Diseases 1983; 19(3): 185-191.
Haris NB, Barletta RG. Mycobacterium avium subsp. paratuberculosis in veterinary medicine. Clin Microbiol Rev 2001; 14: 489-512.
Carrigan MJ, Seaman JT. The pathology of Johne’s diseasein sheep. Aust Vet J 1997; 67(2): 47-50.
Cranwell MP. Control of Johne’s disease in a flock of sheep by vaccination. Vet Rec 1993; 133(9): 219-220.
Gilmour NJL. The pathogenesis, diagnosis and control of Johne’s disease. Vet Rec 1976; 99: 433-434.
Scott PR, Clarke CJ, King TJ. Serum protein concentrations in clinical cases of ovine paratuberculosis (Johne's disease). Vet Rec 1995; 137: 173.
Jones DG, Kay JM. Serum biochemistry and the diagnosis of Johne’s disease (paratuberculosis) in sheep. Vet Rec 1996; 139: 498-499.
Clarke CJ, Little D. The pathology of ovine paratuberculosis: gross and histological changes in the intestine and other tissues. J Comp Pathol 1996; 114: 419- 437.
Luna CL. Manual histologic staining methods of the armed forces institute of pathology. 3rd Edition, New York: Mc Graw Hill Book Company, 1970.
Stewart J, McCallum JW, Taylor AW. Observations on the blood picture of Johne’s disease in sheep and cattle with special reference to the magnesium content of the blood. J Comp Pathol 1945; 55: 45-48.
Patterson DSP, Allen WM, Berrett S, Ivıns LN, Sweasey D. Some biochemical aspects of clinical Johne’s disease in cattle. Res Vet Sci 1968; 9(2): 117-129.
Kopecky KE, Booth GD, Merkal RS, Baetz AL. Certain blood constituent concentration in cattle with paratuberculosis. Am J Vet Res 1972; 33: 2331-2334.
Reddy KP, Sriraman PK, Rao PR. Haematological and biochemical changes in sheep in Johne’s disease. Indian Vet J 1982; 59: 498-502.
Aiello SE. The Merck Veterinary Manual. 8th Edition, Whitehouse Station, N.J., USA: Merck&Co Inc, 1998.
Perez V, Tellechea J, Corpa JM, Gutiearrez M, Garcia MJF. Relation between pathologic findings and cellular immune responses in sheep with naturally acquired paratuberculosis. Am J Vet Res 1999; 1: 123-127.
Clarke CJ, Little D. The pathology of ovine paratuberculosis: gross and histological changes in the intestine and other tissues. J Comp Pathol 1996; 114: 419- 437.
Perez V, Garc ia MJF, Badiola JJ. Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep. J Comp Pathol 1996; 114: 107-122.
Hindson J. Differential diagnosis of weight loss in the ewe. In Pract 1994; 16: 204-208.