Erkeklerde Kullanılan Cerrahi ve Cerrahi Olmayan Kontrasepsiyon Yöntemleri

İnsan ve hayvanlarda aşırı üremeyi önlemek amacıyla eski çağlardan beri kullanılagelen pek çok yöntem hem erkek hem de dişiler için tanımlanmıştır. Üreme faaliyetlerinin devamlı veya geçici bir süre için durdurulması olarak tanımlanan kontrasepsiyonun pratik kullanımı erkeklere oranla dişilerde daha yaygındır. Bununla birlikte, hem insan hem de hayvanların erkek bireylerinde kullanılan değişik kontraseptif yöntemler bulunmaktadır. Cerrahi yöntemler farklı tür erkeklerde radikal bir çözüm olmasına rağmen, bu alanda yapılan çalışmaların büyük çoğunluğu gonadotropin sekresyonunun engellenmesi, hormonlara karşı aşı üretilmesi, farklı bitkiler ve sperm-spesifik- antijenlerin kullanılması gibi cerrahi olmayan yöntemler üzerinde yoğunlaşmaktadır. Testisin ve sperm kanallarının yapısını bozan kimyasal ajanlar, kontrasepsiyonda etkili olmalarına karşın istenmeyen yangısal durumlara ve ağrı gibi yan etkilere neden olmaktadır. Hormonal aşılar, bitkiler ve sperm-spesifik-antijenler genellikle kısa süreli bir kontrasepsiyon sağlamaktadır.

Surgical and Non-surgical Contraception Methods Used in Males

Many methods that have been used preventing overgeneration in humans and animals since ancient times were defined for both males and females. Practical use of contraception, which was defined as the permanent or temporary cessation of reproductive activity, is more common in females than in males. However, there are different contraceptive methods used in males of both humans and animals. Although surgical procedures are the radical solution in different types of males, the vast majority of the works in this field have focused on the non-surgical procedures such as prevention of gonadothropin secretion, producing vaccines against hormones, using different plants, and sperm-specific-antigens. Chemical agents that disrupt the structure of testes and sperm ducts causes undesired side effects such as inflammatory conditions and pain, despite being effective in contraception. Hormonal vaccines, plants and sperm-spesific-antigens often provide a short-term contraception.

___

  • Maenhoudt C, Santos NR, Fontbonne A. Suppression of fertility in adult dogs. Reprod Dom Anim 2014; 49: 58-63. 2. Munks MW. Progress in development of immunocontraceptive vaccines for permanent non-surgical sterilization of cats and dogs. Reprod Dom Anim 2012; 47: 223-227.
  • Bowen RA. Male contraceptive technology for nonhuman male mammals. Anim Reprod Sci 2008; 105: 139-143.
  • Liao AT, Chu PY, Yeh LS, Lin CT, Liu CH. A 12-year retrospective study of canine testicular tumors. J Vet Med Sci 2009; 71: 919-923.
  • McKenzie B. Evaluating the benefits and risks of neutering dogs and cats. CAB Reviews: Persp Agric Vet Sci Nutr Nat Res 2010; 5: 1-18.
  • Mukaratirwa S, Chitura T. Canine subclinical prostatic disease: histologic prevalence and validity of digital rectal examination as a screening test. J South Afr Vet Assoc 2007; 78: 66-68.
  • Overall KL. Clinical Behavioral Medicine for Small Animals. St. Louis, MO: Mosby, 1997.
  • Hart BL, Cooper LC. Factors relating to urine spraying and fighting in prepubertally gonadectomized cats. J Am Vet Med Assoc 1984; 184: 1255-1258.
  • Nabi G. An update on male contraception. J Biol Life Sci 2015; 6: 15-28.
  • Kaya M, Doğan E, Okumuş Z. Köpeklerde vazektominin uzun dönem sonuçlarının değerlendirilmesi. 13. Ulusal Veteriner Cerrahi Kongresi, 27 Haziran-1 Temmuz 2012, Sarıkamış-KARS, 79-80.
  • Johnston SD. Questions and answers on the effects of surgically neutering dogs and cats. JAVMA 1991; 198: 1206-1214.
  • Matthiesson KL, McLachlan RI. Male hormonal contraception: concept proven, product in sight? Hum Reprod Update 2006; 12: 463-482.
  • Tekiner AS, Çetin F, Ceyhun AG, Kafkaslı AK.Planlanmamış gebelikler ile kontraseptif yöntemler arasındaki ilişki. Dirim Tıp Gazetesi 2010; 85: 65-71.
  • İzol V, Değer M, Arıdoğan İA. Erkek kontrasepsiyon yöntemleri. Androloji Bülteni 2013; 15: 117-121.
  • Bearden HJ, Fuquay JW, Willard ST. Applied Animal Reproduction. 6th Edition, New Jersey: Pearson Prentice Hall, Upper Saddle River, 2004.
  • Gündoğan M, Demirci E. Koçlarda scrotal sıcaklık artışının spermatogenesis ve diğer spermatolojik özellikler üzerine etkisi. FÜ Sağ Bil Derg 1999; 13: 193-200.
  • Nieschlag E, Bhere HM. A Texbook of Andrology. 2nd Edition, New York: Springer, 2001.
  • Thakur DS, Kumar P, Kujur A, Kumar P, Kumar R. Contribution of male contraception in world population. J Pharm Sci Res 2010; 2: 384-393.
  • Wright PJ, Stelmasiak T, Black D. Medroxyprogesterone acetate and reproductive processes in male dogs. Aust Vet J 1979; 55: 437-448.
  • England GC. Effect of progestogens and androgens upon spermatogenesis and steroidogenesis in dogs. J Reprod Fertil 1997; 51: 123-138.
  • Freshman JL, Olson PN, Amann RP, et al. The effects of methyltestosteone on reproductive function in male greyhounds. Theriogenology 1990; 33: 1057-1073.
  • Lacoste D, Dube D, Trudel C, Belanger A, Labrie F. Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRH agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide. J Androl 1989; 10: 456-465.
  • Trigg TE, Wright PJ, Armour AF, et al. Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs. J Reprod Fertil Suppl 2001; 57: 255-261.
  • Bertschinger HJ, Asa CS, Calle PP, et al. Control of reproduction and sex related behaviour in exotic wild carnivores with the GnRH analogue deslorelin: Preliminary observations. J Reprod Fertil 2001; 57: 275-283.
  • Bertschinger HJ, Trigg TE, Jochle W, Human A. Induction of contraception in some African wild carnivores by downregulation of LH and FSH secretion using the GnRH analogue deslorelin. Reproduction 2002; 60: 41-52.
  • Bertschinger HJ, Jago M, Nothling JO, Human A. Repeated use of the GnRH analogue deslorelin to downregulate reproduction in male cheetahs (Acinonyx jubatus). Theriogenology 2006; 66: 1762-1767.
  • Naz RK. Anti-sperm contraceptive vaccines: Where we are and where we are going? Review. Am J Reprod Immunol 2011;66:5-12.
  • Yitbarek MB, Regasa F. Reproductive immunization of domestic and wild animals: Review. Int J Sci Tech Res 2014; 3: 399-412.
  • Naz RK, Gupta SK, Gupta JC, Vyas HK, Talwar GP. Recent advances in contraceptive vaccine development: A mini-review. Hum Reprod 2005; 20: 3271-3283.
  • Naz RK. Contraceptive vaccines. Drugs 2005; 65: 593-603.
  • Ladd A, Tsong YY, Walfield AM, Thau R. Development of an antifertility vaccine for pets based on active immunization hormone. Biol Reprod 1994; 51: 1076-1083. luteinizing hormone-releasing
  • Jung MJ, Moon YC, Cho IH. Induction of castration by immunization of male dogs with recombinant gonadotropin- releasing hormone (GnRH)-canine distemper virus (CDV) T helper epitope p35. J Vet Sci 2005; 6: 21-24.
  • Levy JK, Miller LA, Crawford CP, et al. GnRH immunocontraception of male cats. Theriogenology 2004; 62: 1116-1130.
  • Miller LA, Johns BE, Killian GJ. Immunocontraception of white-tailed deer with GnRH vaccine. Am J Reprod Immunol 2000; 44: 266-274.
  • Wagner A, Messe N, Bergmann M, Lekhkota O, Claus R. Effects of estradiol infusion in GnRH immunized boars on spermatogenesis. J Androl 2006; 27: 880-889.
  • Theubet G, Thun R, Hilbe M, Janett F. Effect of vaccination against GnRH (Bopriva®) in the male pubertal calf. Schweiz Arch Tierheilkd 2010; 152: 459-469.
  • Carelli C, Audibert F, Gaillard J, Chedid L. Immunological castration of male mice by a totally synthetic vaccine administered in saline. Proc Natl Acad Sci USA 1982; 79: 5392-5395.
  • Gupta SK, Shrestha A, Minhas V. Milestones in contraceptive vaccines development and hurdles in their application. Hum Vaccin Immunother 2014; 10: 911-925.
  • Lunnen JE, Faulkner LC, Hopwood ML, Pickett BW. Immunization of dogs with bovine luteinizing hormone. Biol Reprod 1974; 10: 453-460.
  • Ascoli M, Fanelli F, Segaloff DL. The lutropin / choriogonadotropin receptor, a 2002 perspective. Endocr Rev 2002; 23: 141-174.
  • Remy JJ, Bozon V, Couture L, et al. Suppression of fertility in male mice by immunization against LH receptor. J Reprod Immunol 1993; 25: 63-79.
  • Srinath BR, Wickings EJ, Witting C, Nieschlag E. Active immunization with follicle-stimulating hormone for fertility control: A 4 1/2-year study in male rhesus monkeys. Fertil Steril 1983; 40: 110-117.
  • Moudgal NR, Ravindranath N, Murthy GS, et al. Long-term contraceptive efficacy of vaccine of ovine follicle- stimulating hormone in male bonnet monkeys (Macaca radiata). J Reprod Fertil 1992; 96: 91-102.
  • Devic S, Jain T, Hazarika T, et al. Anti-sperm contraceptive vaccines: A hypothesis to devise a new, innovative contraceptive against sperms inside a woman's uterus. Int J Pharm Pharmaceut Sci 2013; 5: 24-5.
  • Pineda MH, Reimers TJ, Faulkner LC, Hopwood ML, Seidel GE Jr. Azoospermia in dogs induced by injection of sclerosing agents into the caudae of the epididymides. Am J Vet Res 1977; 38: 831-838.
  • Kutzler M, Wood A. Non-surgical methods of contraception and sterilization. Theriogenology 2006; 66: 514-525.
  • Naz RK, Talwar GP. Immunological sterilization of male dogs by BCG. Int J Androl 1981; 4: 111-128.
  • Dixit VP. Chemical sterilization of male dogs (canis familiaris) after single intratesticular administration of methalibure (ICI-33828), dexamethasone, metoprion (SU- 4885, Ciba), niradazole (33644-Ba, Ciba) ?-chlorohydrin (U-5897) and danazol. Indian J Exp Biol 1979; 17: 937- 940.
  • Anonim. "Esterilsol TM ("Zinc Neutering"). Alliance for Contraception in Cats and Dogs (ACC&D), 2012". http://www.stray-afp.org/wp-content/uploads/2012/07/ Esterilsol-Product-Profile-and-Position-Paper.pdf/ 01.06.2015.
  • Levy JK, Cynda Crawford PC, Appel LD, Clifford EL. Comparison of intratesticular injection of zinc gluconate versus surgical castration to sterilize male dogs. Am J Vet Res 2008; 69: 140-143.
  • Günay C, Sağlıyan A, Yaman İ, Sönmez M, Türk G. Erkek köpeklerde intratestiküler gliserol ve etanol uygulamalarının kısırlaştırma üzerine etkilerinin karşılaştırılması. Veteriner Cerrahi Dergisi 2004; 10: 55-60.
  • Canpolat İ, Gür S, Günay C, Bulut S, Eröksüz H. An evaluation of the outcome of bull castration by intra- testicular injection of ethanol and calcium chloride. Rev Med Vet 2006; 157: 420-425.
  • Jana K, Samanta PK. Sterilization of male stray dogs with a single intratesticular injection of calcium chloride: A dose- dependent study. Contraception 2007; 75: 390-400.
  • Pineda MH, Dooley MP. Surgical and chemical vasectomy in the cat. Am J Vet Res 1984; 45: 291-300.
  • Lohiya NK, Alam I, Hussain M, Khan SR, Ansari AS. RISUG: An intravasal injectable male contraceptive. Indian J Med Res 2014; 140: 63-72.
  • Qian SZ. Tripterygium wilfordii: A Chinese herb effective in male fertility regulation. Contraception 1987; 36: 247-263.
  • Yu DY. One hundred and and forty -four cases of rheumatoid arthritis treated with Tripterygium wilfordii. J Tradit Chinese Med 1983; 3: 125-129.
  • Qian SZ, Zhong CQ, Xu Y. Effect of Tripterygium wilfordii on the fertility of rats. Contraception 1986; 33: 105-110.
  • Hamman WO, Musa SA, Ikyembe DT, et al. Ethanol extract of Carica papaya seeds induces reversible contraception in adult male wistar rats. Br J Pharmacol Toxicol 2011; 2: 257-261.
  • Adienbo OM, Nwafor A, Ogbomade RS. Contraceptive efficacy of hydro-methanolic fruit extract of Xylopia aethiopica in male albino rats. Int J Adv Biol Biomed Res 2013; 1: 718-727.
  • Kasturi M, Manivannan B, Ahamed RN, Shaikh PD, Pathan KM. Changes in epididymal structure and function of albino albino rat treated with Azadirachta indica leaves. Indian J Exp Biol 1995; 33: 725-729.
  • Rao MV, Shah KD, Rajani M. Contraceptive effects of Phyllanthus amarus extract in the male mouse. Phytother Res 1997; 11: 594-596.
  • Rao MV, Shah KD, Rajani M. Contraceptive efficacy of Balanites roxburghii pericarp extract in male mice (Mus musculus). Phytother Res 1997; 11: 469-471.
  • Purandare TV, Kholkute SD, Gurjar A, et al. Semen analysis and hormonal levels in bonnet macaques administered Embelia ribes berries, an indigenous plant having contraceptive activity. Indian J Exp Biol 1979; 17: 935-936.
  • Dixit VP, Bhargava SK. Reversible contraception like activity of embelin in male dogs (Canis indicus Linn). Andrologia 1983; 15: 486-494.
  • Nya-Ngatchou JJ, Amory JK. New approaches to male non-hormonal contraception. Contraception 2013; 87: 296- 299.
  • Singh AP, Rajender S. CatSper channel, sperm function and male fertility. Reprod Biomed Online 2015; 30: 28-38.
  • Walden CM, Butters TD, Dwek RA, Platt FM, van der Spoel AC. Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin. Hum Reprod 2006; 21: 1309-1315.
  • Fahim MS, Fahim Z, Harman J, et al. Ultrasound as a new method of male contraception. Fertil Steril 1977; 28: 823- 831.