Sema TİMURKAAN, Ömer ATALAR, Meryem KARAN

The localization of insulin, glucagon, somatostatin immunoreactive cells in the pancreas of the Martes foina

Bu çalışmada, sansar pancreas'ında insülin, glukagon, ve somatostatin antiserumları kullanarak 3 çeşit immunoreaktif hücre saptandı. Bu immunoreaktif hücrelerin, Langerhans adacıklarındaki bölgesel dağılımları ve nisbi sıklıklarının farklı olduğu incelendi. İnsülin'e immunoreaktif hücreler en fazla merkezi bölgelerde olmakla birlikte, birkaç tanesi de ara bölgede görüldü. Glukagon'a immunoreaktif hücreler, başlıca ara bölgeyle sınırlandıysa da, bu hücrelerin birkaç tanesi merkezi kısımlarda görüldü. Bununla birlikte nadir örnekleri periferal bölgede bulundu. Somatostatin immunoreaktif hücreler orta derece ve seyrek olarak ara bölge ile periferal bölgelerde saptandı. Bununla birlikte somatostatin immunoreaktif hücreler ekzokrin kısımlarda saptanmadı.

İnsülin, glukagon ve somatostatin immunoreaktif hücrelerinin sansar pankreas'ındaki lokalizasyonu

In this study, three kinds of the immunoreactive endocrine cells were detected using to insulin, glucagon and somatostatin antisera in the pancreas of the Martes foina. Different regional distributions and relative frequencies of these immunoreactive cells were observed in the different pancreatic regions. Insulin immunoreactive cells were located in the central regions with high frequency, and a few of these cells were also demonstrated in the mantle zones. Glucagon immunoreactive cells were mainly restricted to mantle zones but a few of these cells were also demonstrated in the central zones. Howewer; rare examples were found in the peripheral regions. Somatostatin immunoreactive cells were detected in the mantle zones and peripheral regions with moderate and rare frequencies, respectively. However, somatostatin immunoreactive cells were not demonstrated in the exocrine portions.

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