Ratlarda homosisteinin oksidan-antioksidan sistem ve koroner damarlarda oluşturduğu değişiklikler üzerine melatoninin etkisi

Bu çalışma, uzun süreli homosistein uygulanan radarda antioksidan enzim düzeyleri ve koroner arterlerin yapısındaki değişimler ve bu değişimlere melatoninin etkilerini araştırmak amacıyla yapılmıştır. Bu amaçla 30 dişi ve 30 erkek, toplam 60 Wistar albino rat kullanıldı. Hayvanlar rasgele 3 gruba ayrıldı. Bu gruplar kontrol, homosistein ve melatonin grupları olarak isimlendirildi. Altı hafta boyunca her gün kontrol grubuna serum fizyolojik, homosistein grubuna 0.71 mg/kg homosistein periton içi, melatonin grubuna da 0.71 mg/kg homosistein (ip) + 1 mg/kg melatonin derialtı olarak uygulandı. Plazma homosistein, Malondialdehit (MDA) ve doku MDA düzeyleri kontrol grubuyla karşılaştırıldığında homosistein grubunda önemli derecede (P

Effect of melatonin on homocysteine-Induced changes in oxidant-antioxidant systems and coronary arteries in rats

This study was conducted to investigate the changes in the levels of antioxidant enzyme and structure of coronary arteries in long-term homocysteine administered rats and to investigate the effects of melatonin on these changes. For this purpose, 30 male and 30 female Wistar albino rats were used. The rats were randomly divided into 3 groups. These groups were named as control, homocysteine and melatonin. Normal saline was intraperitoneally administered to the control group; dl-homocysteine (0.71 mg/kg) was intraperitoneally administered to the homocysteine group; dl-homocysteine (0.71 mg/kg, intraperitoneally) + melatonin (1 mg/kg, subcutaneous) were administered to the melatonin group, daily for 6 weeks. Compared to the control group, levels of plasma homocysteine, MDA and tissue MDA significantly (P

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