BETÜL DEMİR, DEMET ÇİÇEK, Leyla BİLİK, Ebru GÜLER AYDOĞDU, Nida DEMİRPOLAT, Can ERGİN

Oral Isotretinoin Induced Pigmentation Disorder: A Case Report

İlaçlarla gelişen hiperpigmentasyonlar genellikle ilacın deride birikimine bağlıdır. İsotretinoin A vitamininin sentetik derivesidir ve retinoidlerin 13- cis retinoik asit formudur. Yirmi yaşında kadın hasta burunda kahverengi leke şikayeti ile dermatoloji polikliniğine başvurdu. Hastanın hikayesinden son altı aydır akne tedavisi için 30 mg/gün isotretinoin kullandığı, beraberinde başka oral veya topikal bir ilaç kullanmadığı öğrenildi. Dermatolojik muayenesinde sol burun kanadında 1x1 cm çaplı gri renkte makül mevcuttu. Lezyonun dermatoskopik muayenesinde sol burun kanadında özellikle foliküler açıklıkların etrafını saran ince, gri renkte pigmente yapılar görüldü. Literatürde oral isotretinoin kullanımına bağlı gelişen pigmentasyon bozukluğuna rastlamamış olmamız bizi bu olguyu sunmaya teşvik etmiştir.

O ral İsotretinoinin Tetiklediği Pigmentasyon Bozukluğu: Olgu Sunumu

Hyperpigmentation, which develops secondary to drugs, is generally due to the accumulation of the drugs on the skin. Isotretinoin is synthetic derivative of vitamin A and it is the 13-cis retinoic acid form of a retinoid. A 20-year-old female patient presented to the dermatology outpatient clinic with complaints of brown stains on the nose. The medical history also revealed that the patient had been using isotretinoin 30 mg/day for the last six months for acne and no other oral or topical drug use was present. Her dermatological examination revealed that a gray macule of1x1 cm was present in the left nasal wing. The dermatoscopic examination of the lesion revealed thin, gray, pigmented structuresin particular, surrounding the follicular openings. The absence of pigmentation defects due to systemic isotretinoin use in the literature review has led us to present the current case.

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