Bora ÇOŞKUN, Buğra ÇOŞKUN, Coşkun ŞİMŞİR, Demet KOKANALI, Eser ÇOLAK, İrem Eda GÖKDEMİR, Şevki ÇELEN

İkinci Trimester Maternal Serum Belirteçleri ve Doğum Ağırlığı Arasındaki İlişki

Amaç: Komplike olmayan gebeliklerde, ikinci trimester prenatal tarama serum belirteç düzeylerinden herhangi birinin doğum ağırlığı ile anlamlı bir ilişkisi olup olmadığını belirlemeyi amaçladık. Gereç ve Yöntem: Bu retrospektif çalışmaya SBÜ Zekai Tahir Burak Sağlık Uygulama ve Araştırma Merkezi Kadın Hastalıkları ve Doğum Kliniğinde doğum yapan ve ikinci trimesterda (16-18 hafta) anöploidi taraması yapılmış 540 gebe dahil edildi. Tüm kadınların son adet tarihi ilk trimester ultrasonu ile teyit edildi. Maternal serum alpha-fetoprotein (AFP), β-insan koryonik gonadotropin (hCG) ve konjuge olmayan estriol (uE3) değerleri medyanın (MoM) katları olarak hesaplandı. İkinci trimester serum belirteç düzeyleri ile bebek doğum ağırlıklarının arasındaki ilişkiler korelasyon analizi ile değerlendirildi. Katkıda bulunan çeşitli faktörlerin doğum kilosu üzerindeki etkileri lineer regresyon analizi ile araştırıldı. Bulgular: Tarama sırasındaki maternal yaş (r =-0.48; p =0.03) ve maternal serum AFP düzeyi (r =-0.45; p =0.03) ile yenidoğan doğum ağırlığı arasında anlamlı negatif korelasyon vardı. Ayrıca, hamilelikte kilo alımı miktarı (r =0.44; p =0.04) ve maternal serum uE3 düzeyi (r =0.47; p =0.03) ile yenidoğan doğum ağırlığı arasında pozitif korelasyon vardı. Tarama sırasındaki maternal ağırlık, VKİ ve maternal serum β hCG düzeyi ile yenidoğanın doğum ağırlığı arasında anlamlı bir korelasyon görülmedi. Bununla birlikte maternal serum uE3 düzeyi, lineer regresyon modelinde doğum ağırlığını etkileyen tek faktör olarak izlendi. Sonuç: İkinci trimester maternal serum uE3 düzeyi, komplike olmayan hamile kadınlarda doğum ağırlığını öngörmede faydalı olabilir.

Association Between Second Trimester Maternal Serum Markers and Birth Weight

Objective: We aimed to determine if any of the second trimester serum marker levels had a significant association with birth weight in uncomplicatedpregnancies.Material and Method: Five hundred and forty pregnant women whose second trimester (16-18 weeks) aneuploidy screening and delivery was performed at SBU Zekai Tahir Burak Health Application and Research Center Obstetrics and Gynecology Clinic, are included in this retrospective study.All women had their last menstrual period confirmed by their first trimester ultrasound. Levels of maternal serum alpha-fetoprotein (AFP), β-humanchorionic gonadotropin (hCG), and unconjugated estriol (uE3) were calculated as coefficients of the median (MoM). Associations between the secondtrimester markers levels and infant birth weights were assessed using correlation analysis. The effects of various contributing factors on birth weightwere investigated with linear regression analysis.Results: There were significant negative correlations between maternal age at screening (r =-0.48; p =0.03), maternal serum AFP level (r =-0.45; p=0.03) and birth weight of the newborn. Besides, there were positive correlations between amount of weight gain during pregnancy (r =0.44; p =0.04),maternal serum uE3 level (r =0.47; p =0.03) and birth weight of newborn. However, maternal weight and BMI at screening and maternal serum β hCGlevel did not have a significant correlation with birth weight of newborn. However, maternal serum uE3 level was the only factor that affected thebirth weight on linear regression model.Conclusion: Second trimester maternal serum uE3 level might be useful in predicting birth weight among uncomplicated pregnant women.

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