Göğüs Duvarında Dermatofibrosarkoma Protuberans: Olgu Sunumu
Dermatofibrosarkom protüberans nadir görülen lokal, agresif bir tümördür. Küçük boyutlu başlayıp cilt, cilt altı, kas ve kemiğe infiltre olabilir. Tanı, fizik muayene, manyetik rezonans görüntüleme ve bilgisayarlı tomografi ile konur. Tedavisi geniş güvenlik sınırları içeren cerrahi rezeksiyondur. Çalışmamızda, göğüs duvarında nadir görülen dermatofibrosarkom protuberans olgusunu paylaşmayı amaçladık.
Dermatofibrosarcoma Protuberans on Chest Wall: Case Report
Dermatofibrosarcoma protuberans is a rare, locally aggressive tumor. Inception may be small in size and can infiltrate to skin, subcutaneous tissue, muscle and bones. Diagnosis is made by physical examination, magnetic resonance imaging and computed tomography. The treatment is surgical resection with extensive safety margin. In our study, we aimed to share a rare dermatofibrosarcoma protuberance case on the chest wall.
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- Fiore M, Miceli R, Mussi C, Lo Vullo S, Mariani
L, Lozza L, et al. Dermatofibrosarcoma protuberans
treated at a single institution: a surgical disease
with a high cure rate. J Clin Oncol 2005; 23:
7669-75.
- Kransdorf MJ, Meis Kindblom JM. Dermatofibrosarcoma
protuberans: radiologic appearance. AJR
Am J Roentgenol 1994; 163: 391-4.
- Turgut AT, Koşar U, Ergeneci A, Çakmak H.
Lokal rekürens bulunmaksızın akciğer metastazı
gösteren dermatofibrosarkom protüberans. Türk
Tanısal ve Girişimsel Radyoloji Dergisi 2003; 9:
195-8.
- Dimitropoulos VA. Dermatofibrosarcoma protuberans.
Dermatol Ther 2008; 21: 428-32.
- Simon MP, Pedeutour F, Sirvent N, et al. Deregulation
of the platelet-derived growth factor B-chain
gene via fusion with collagen gene COL1A1 in
dermatofibrosarcoma protuberans and giant-cell
fibroblastoma. Nat Genet 1997; 15: 95-8.
- McArthur G. Molecularly targeted treatment for
dermatofibrosarcoma protuberans. Semin Oncol
2004; 31: 30-6.
- Shimizu A, O'Brien KP, Sjoblom T, et al. The
dermatofibrosarcoma protuberans-associated collagen
type I alpha1/platelet-derived growth factor
(PDGF) B-chain fusion gene generates a transforming
protein that is processed to functional
PDGF-BB. Cancer Res 1999; 59: 3719-23.
- Ruiz Tovar J, Fernández Guarino M, Reguero
Callejas ME, Aguilera Velardo A, Arano Bermejo
J, Cabañas Navarro L. Dermatofibrosarcoma protuberans:
review of 20-years experience. Clin
Transl Oncol 2006; 8: 606-10.
- Patil PK, Patel SG, Krishnamurthy S, Mistry RC,
Deshpande RK, Desai PB. Dermatofibrosarcoma
protuberans metastatic to the lung. A case report.
Tumori 1992; 78: 49-51.
- Murphy SJ. Dermatofibrosarcoma protuberans:
Early recognition and treatment. Am Fam Physician
2000; 62: 1257-8.
- Kimmel Z, Ratner D, Kim JY, Wayne JD, Rademaker
AW, Alam M. Peripheral excision margins
for dermatofibrosarcoma protuberans: a metaanalysis
of spatial data. Ann Surg Oncol 2007; 14:
2113-20.
- Uysal B, Sager O, Gamsiz H, Cicek A, Demiral S,
Dincoglan F, et al. Evaluation of the role of radiotherapy
in the management of dermatofibrosarcoma
protuberans. J BUON 2013; 18: 268-73.