Derya ALTAY, Hatice Gamze POYRAZOĞLU, Yaşar DOĞAN

İdiopatik Epilepsili Çocuklarda Çölyak Hastalığı Sıklığı

Amaç: Çölyak hastalığının gastrointestinal sistem dışı bulgularından biri de epilepsidir. Bu çalışmada idiopatik epilepsi nedeniyle araştırılan çocuklarda çölyak hastalığı sıklığının belirlenmesi amaçlandı. Gereç ve Yöntem: Fırat Üniversitesi Hastanesi Çocuk Nöroloji Polikliniği’nde Haziran 2016 ile Mart 2017 tarihleri arasında idiopatik epilepsi tanısı alan çocuk hastalar çalışmaya alındı. Tüm hastaların serum anti doku-transglutaminaz IgA ve IgA düzeylerine bakıldı, pozitiflik saptanması durumunda duodenal biyopsi ile çölyak hastalığı tanısı kesinleştirildi. Bulgular: Toplam 109 epileptik hasta çalışmaya alındı. Hastaların ortalama yaşı 8.61+4.67 yıl olup 57’si (%52.3) erkek cinsiyet idi. Bütün olguların serum IgA düzeyleri normal sınırlarda idi. Serum anti doku-transglutaminaz IgA pozitifliği sadece bir olguda (%0.91) saptandı ve duodenal biyopsi sonucu Marsh 3b idi. Sonuç: İdiopatik epilepsi tanısı konulan çocuklar çölyak hastalığı semptomları açısından sorgulanmalı, gerekirse tarama yapılmalıdır.

Frequency of Celiac Disease in Children with Idiopathic Epilepsy

Objective: One of the extra-intestinal findings of celiac disease is epilepsy. In this study, it was aimed to determine the prevalence of celiac disease in children investigated for idiopathic epilepsy. Material and Method: In this study, pediatric patients with a complaint of seizure who admitted to the Pediatric Neurology Department of Fırat University Hospital were included between June 2016 and March 2017. Serum anti tissue-transglutaminase IgA and IgA levels were measured in all patients, diagnosis of celiac disease was confirmed by duodenal biopsy if anti tissue-transglutaminase IgA positivity was detected. Results: A total of 109 epileptic patients were included in this study. Mean age of the patients were 8.61+4.67 years and 57 (52.3%) patients were male gender. All cases had normal serum IgA levels. Serum antitissue-transglutaminase IgA positivity was detected in only one case (0.91%) and the duodenal biopsy of this patient was Marsh 3b. Conclusion: Patients diagnosed with idiopathic epilepsy should be questioned for celiac disease symptoms and screened if necessary.

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