Çocuklarda Aminotransferaz Yüksekliği

Vücudumuzun en büyük iç organı olan karaciğer; metabolik, hematopoetik ve immün bir organdır. Pek çok fonksiyonu olmasından dolayı ilaçlar, enfeksiyonlar gibi dış faktörlerden etkilenebilirliği de o kadar fazladır. Aminotransferazlar, karaciğer hasarı veya hastalığını değerlendirmede sıklıkla kullanılan biyokimyasal testlerdir. Aspartat aminotransferaz (AST) ve alanin aminotransferazı (ALT) içeren bu testler klinik pratikte tam karşılığı olmasa da karaciğer fonksiyon testleri olarak bilinmektedir. Rutin poliklinik kontrollerinde sıklıkla bakılan aminotransferazların yine sıklıkla hafif derecede yüksekliği ile karşılaşılmaktadır. Bu durumda çocuk gastroenteroloji bölümü ile konsulte edilen hastalara ayrıntılı değerlendirme yapılmaktadır. Bu derlemede aminotransferaz yüksekliğine neden olan hastalıklar gözden geçirilmiştir.

Aminotransferase Levels in Children

Liver, the largest internal organ of our body, is a metabolic, hematopoietic and immune organ. Due to its many functions, liver may be commonly impacted by external factors such as drugs and infections. For the evaluation of the liver damage or disease, aminotransferases are frequently used as biochemical tests. These tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), are known in clinical practice as liver function tests, inadvertently. Serum aminotransferase levels are measured often during routine policlinic controls of the patients and levels are frequently observed as slightly high. In this instance, further through evaluation is performed to the patients by consulting with pediatric gastroenterology department. In this review, diseases that cause aminotransferase elevation were revised.

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