Phytochemical And Antimicrobial Study of Glycosmis mauritiana (Lam.) Tanaka

We have successfully extracted a novel geranyl flavanone from the root barks of Glycosmis mauritiana. The structucture was eleducated as 6-geranyl-5-hydroxy-3′ -methoxy-7, 8- (2", 2"-dimethyl pyrano) flavanone- 4'-O-D-glucopyranoside (GM-1), along with 3 known compounds (GM-2, GM-3, GM-4), was separated and identified by a variety of spectroscopic techniques. The range of inhibition against four bacteria examined was shown to be 4-25 mm; the GM-1 revealed a significant inhibition zone.

Keywords:

Rutaceae, Glycosmis mauritiana, Flavanone,

PDF

___

Agrawal P. (1989). Carbon-13 NMR of Flavonoids. Amsterdam: Elsevier Science.
Andersen O M. and Markham K R. (2006) Flavonoids Chemistry, Biochemistry and Applications, CRC Press, Taylor and Francis, Boca Raton. https://doi.org/10.1201/9781420039443
Blanco Carcache P, Anaya Eugenio G, Ninh T, Moore C, Rivera-Chávez J, and Ren Y. (2022). Cytotoxic constituents of Glycosmis ovoidea collected in Vietnam. Fitoterapia, 162, 105265. https://doi.org/10.1016/j.fitote.2022.105265
Chakraborty M. (2022). Identification of Naturally Occurring Carbazole Alkaloids Isolated from Murraya koenigii & Glycosmis pentaphylla by the Preparation of HPLC Fingerprint. Journal of Scientific Research, 14(1), 289-300. https://doi.org/10.3329/jsr.v14i1.53526
Harborne J. (1986) The Flavonoids Advances in Research Since 1986. Routledge
Hofer O and Greger H. (2000). Sulfur-Containing Amides from Glycosmis Species (Rutaceae). In: Herz W, Falk H, Kirby, G W, and Moore R E. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 80. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6331-3_2
Intekhab J, Aslam M, and Khalid H. (2011). Phytochemical Study of Glycosmis Mauritiana American Journal of Plant Sciences, 02(05), 657-659. https://doi.org/10.4236/ajps.2011.25078 Khare C, and Khare C. (2011). Indian Medicinal Plants: An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg.
Mabry T J, Markham K R, and Thomas M B. (1970) The Systematic Identification of Flavonoids, Springer, New York. https://doi.org/10.1007/978-3-642-88458-0
Markham, K.R., Chari, V.M. (1982). Carbon-13 NMR Spectroscopy of Flavonoids. In: Harborne, J.B., Mabry, T.J. (Eds.) The Flavonoids. Springer, Boston, MA. Pp.19-134. https://doi.org/10.1007/978-1-4899-2915-0_2
Phillips W R, Baj N J, and Gunatilaka Kingston, A A L. (1996) C Geranyl compounds from Mimulus clevelandii. J. Nat. Prod. 59, 495–497. https://doi.org/10.1021/np960240l
Smejkal K, Grycova´ L, Marek R, Lemie`Re F, Jankovska´ D, Forejtni´Kova´ H, Vanco J, and Suchy V. (2007) C-Geranyl compounds from Paulownia tomentosa fruits. J. Nat. Prod. 70, 1244–1248. https://doi.org/10.1055/s-2008-1081339
Yasir M, Tripathi M, Singh P, and Shrivastava R. (2019). The Genus Glycosmis [Rutaceae]: A Comprehensive Review on its Phytochemical and Pharmacological Perspectives. The Natural Products Journal, 9(2), 98-124. https://doi.org/10.2174/2210315508666180622121212