The Potency of Beligo Seeds (Benincasa hispida (Thunb.) Cogn.) as Antihyperlipidemic in L-NAME-induced Hyperlipidemic Rats

Beligo or Bligo is the name of Benincasa hispida (Thunb.) Cogn. in Indonesian, is empirically used in the treatment of cholesterol and hypertension. The part of the plant used is the seed. This have a look at aimed to determine the antihyperlipidemic activity of beligo seeds in L-NAME-induced hyperlipidemic rats. Male albino rats (n= 25) were divided into 5 groups: Sod. CMC 1%, plant extract (100 mg/kg, 200 mg/kg, 300 mg/kg body weight), and Simvastatin were induced by L-NAME 40 mg/kg BW for 4 weeks. Measurement of lipid profile levels consisting of TC, HDL, LDL, TG, and VLDL, using a human analyzer (Thermo Scientific Indico®). L-NAME was shown to significantly (p<0.05) improve lipid profile levels. The results showed that beligo seed ethanol extract (BSEE) at a dose of 200 mg/kg BW, 300 mg/kg BW can reduce significantly (p<0,05) levels of TC, TG, and LDL and can increase significantly (p<0,05) HDL levels. While a dose of 100 mg/kg BW can only reduce significantly (p<0,05) TC and TG levels and only a dose of 300 mg/kg BW can reduce VLDL significantly (p<0,05).

Keywords:

Benincasa hispida (Thunb.) Cogn. Seed, Hyperlipidemic, L-NAME Lipid profile,

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