Eren GÜNDÜZ, Pınar SIRMATEL, Hülya YILMAZ

Otolog hematopoietik kök hücre nakli yapılan lenfomalı hastalarda malign olmayan geç etkiler

Amaç: Nakil işlemlerindeki gelişmeler hematopoietik kök hücre nakli (HKHN) sonrası uzun süre yaşayan hasta sayısında artışa neden olmuştur. Biz bu çalışmada lenfomalı hastalarda otolog HKHN sonrası malign olmayan geç yan etkileri araştırdık.Yöntemler: Hastalar immün sistem, göz, akciğer, kalp, karaciğer ve böbrek fonksiyon testleri ile değerlendirildi. Bulgular: Dokuz (%26) hastada lenfopeni saptandı. Katarakt tek göz komplikasyonuydu. Dört (%11,4) hastada obstrüktif ve 8 (%22,9) hastada restriktif tip akciğer fonksiyon anormalliği mevcuttu. Yalnızca 1 hastada semptomatik kalp yetmezliği vardı. Bir hastada renal yetmezlik gelişmişti. Erkek hastaların %53'ü impotans tarifledi. En sık endokrin anormallik hipotiroidi idi. Beş (%14,2) hastada osteoporoz saptandı.Sonuç: Otolog HKHN sonrası malign olmayan geç etkilere ilişkin yeterli veri yoktur. Kontrol grubunun olmaması bir kısıtlılık olmakla birlikte, sonuçlarımız otology HKHN yapılan hastaların malign olmayan nakil geç yan etkileri açısından takip edilmesinin önemini vurgulamaktadır.

Non-malignant late effects in lymphoma patients treated with autologous hematopoietic stem cell transplantation

Objective: Developments in transplantation procedures have led to an increase in the number of long-term survivors after hematopoietic stem cell transplantation (HSCT). In this study, we investigated non-malignant late side effects after autologous HSCT (AHSCT) in lymphoma patients. Methods: Patients were evaluated for immune system, eye, lung, heart, liver, kidney, and endocrine function tests. Results: Nine (26%) patients had absolute lymphopenia. Cataract was the only eye complication. Four (11.4%) patients had obstructive- and 8 (22.9%) had restrictive-type pulmonary function abnormalities. Only one patient had symptomatic heart failure. One patient developed renal failure. Fifty-three percent of male patients described impotence. The most frequent endocrine disorder was hypothyroidism. Five (14.2%) patients had osteoporosis. Conclusion: There is not enough data on the non-malignant late effects after AHSCT. Although the lack of a control group is a limitation of our study, our results emphasize the importance of following AHSCT patients for non-malignant late effects of transplantation.

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