Abuzer ÇELEKLİ, Mustafa ARAZ, Rahma HAMİD, Zeynel Abidin SAYİNER

Obez ve Obez Olmayan Diabetik Hastalarda İnsulin Direnci ile Serum Magnezyum Düzeyi İlişkisi

Amaç: Tip 2 diabetes mellitus (T2DM) ve obezite kalıtsal ve çevresel faktörler arasındaki etkileşimler de dahil olmak üzere multifaktöriyel hastalıklardır. Çalışmamızın amacı diyabetik olmayan kişilerde ve obez T2DM hastalarda serum Magnezyum (Mg) düzeyleri ile insülin direnci (HOMA-IR) arasındaki ilişkiyi değerlendirmektir. Yöntemler: Çalışmamız her iki cinsiyetten (20-70) yaş aralığında olan 120 denekten oluşmaktadır. Denekler dört gruba ayrıldı: Grup I kontrol olarak 30 sağlıklı bireyi (8 erkek 22 kadın) içeriyordu. Grup II, BMI ≥25 kg/m2 olan 30 obez diyabetik olmayan (6 erkek 24 kadın) denekten oluşmaktaydı. Grup III, hastalık öyküsü bir yıldan az olan 30 (14 erkek 16 kadın) obez T2DM hastasını ve beşinci yıldan fazla hastalığa sahip 30 (17 erkek ve 13 kadın) obez T2DM’yi grup IV’te gruplandırdı. T2DM hastalarının tanı endokrinoloji ve metabolizma uzmanları tarafından yapıldı. Serum Mg, açlık glikozu, açlık insülini ve açlık lipidleri ölçüldü, ağırlık, boy ölçülür. Ek olarak vücut kitle indeksi (VKI) ve HOMA-IR hesaplandı. Bulgular: Serum Mg düzeyi grup I’de (1,72±0,1mg/dL) grup I’e (2,07±0,1mg/dL) göre anlamlı şekilde düşüktü (p

Relationship between Serum Magnesium Level and Insulin Resistance in Obese Non-Diabetic and Diabetic Patients

Objective: Type 2 diabetes mellitus (T2DM) and obesity are multifactorial diseases that include interactions between hereditaryand environmental factors. Our study aimed to evaluate the relationship between serum magnesium (Mg) level and insulin resistance (HOMA-IR) in obese non-diabetic subjects and obese patients with T2DM who were compared with healthy controls.Methods: The present study included 120 subjects of both genders (age, 20-70 years). The subjects were divided into four groups:Group I included 30 healthy subjects as control (8 males and 22 females); group II included 30 obese non-diabetic subjects (6 malesand 24 females) with the body mass index (BMI) ≥25 kg/m2; group III included 30 (14 males and 16 females) obese patients withT2DM and disease history 5 years. Endocrinology and metabolism specialists diagnosed T2DM patients. Serum Mg, fasting glucose, fasting insulin, andfasting lipids were measured including the patients’ weight and height. In addition, BMI and HOMA-IR were calculated.Results: Serum Mg level significantly decreased in group IV (1.72±0.1 mg/dL) compared with group I (2.07±0.1 mg/dL; p

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