COVID-19 Seroprevalence among Healthcare Workers in a University Hospital in Southeastern Turkey
COVID-19 Seroprevalence among Healthcare Workers in a University Hospital in Southeastern Turkey
Objective: In our study, IgG and IgA antibodies were investigated by using the ELISA method, especially in healthcare workers (HCWs) who were more likely to encounter infection as of June 2020, and it was aimed to determine the level of HCWs being affected by the pandemic. Methods: A total of 186 volunteer HCWs from different professions working in different departments were included in the study. Serum was obtained by taking 5 mL of blood samples from the volunteers. The presence of IgA and IgG antibodies against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus was investigated in the sera by using the ELISA method. Results: The mean age of the participants in the study was 34.22 (67.85), and 71 (38.2%) were female. One hundred and eighty partici pants tested for SARS-CoV-2 IgA antibodies, and eight (4.4%) of them were found positive. One hundred and eighty-six participants tested for SARS-CoV-2 IgG antibodies, and five (2.7%) of them were found positive. The highest antibody positivity was detected in the intensive care unit and doctors. Conclusion: At the end of the study, low seropositivity rates were found. However, the risk of infection in HCWs increased in proportion to the continuation of the pandemic and the increase in cases. HCWs took the necessary precautions to minimize the infection. Investi gating the presence of antibodies in HCWs at regular intervals will help to calculate the risk among HCWs.
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- 1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-733. [CrossRef]
- 2. World Health Organization: WHO director-general’s opening remarks at the media briefing on COVID-19-11. Accessed 27 October 2020. [CrossRef]
- 3. World Health Organization: WHO coronavirus disease (COVID-19) weekly epidemiological update. Accessed 27 October 2020. [CrossRef]
- 4. Health Ministry of Turkey: Daily report of COVID-19. Accessed 1 November 2020. [CrossRef]
- 5. Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: Implication of multiple shedding routes. Emerg Microbes Infect. 2020;9:386-389 [CrossRef]
- 6. To KK, Tsang OT, Leung WS, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: An observational cohort study. Lancet Infect Dis. 2020;20:565-574. [CrossRef]
- 7. Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. 2020;ciaa344. [CrossRef]
- 8. Li Z, Yi Y, Luo X, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020. [CrossRef]
- 9. Ma H, Zeng W, He H, et al. Serum IgA, IgM, and IgG responses in COVID-19. Cell Mol Immunol. 2020;17:773-775. [CrossRef]
- 10. Hoelh S, Rabenau H, Berger A, et al. Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China. N Engl J Med. 2020;382:1278-1280. [CrossRef]
- 11. Ng K, Poon BH, Kiat Puar TH, et al. COVID-19 and the risk to health care workers: A case report. Ann Intern Med. 2020;172:766-767. [CrossRef]
- 12. Black JRM, Bailey C, Przewrocka J, Dijkstra KK, Swanton C. COVID19: The case for health-care worker screening to prevent hospital transmission. Lancet. 2020;395:1418-1420. [CrossRef]
- 13. Korth J, Wilde B, Dolff S, et al. SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patients. J Clin Virol. 2020;128:104437. [CrossRef]
- 14. Chen Y, Tong X, Wang J, et al. High SARS-CoV-2 antibody prevalence among healthcare workers exposed to COVID-19 patients. J Infect. 2020;81:420-426. [CrossRef]
- 15. Rudberg AS, Havervall S, Manberg A, et al. SARS-CoV-2 exposure, symptoms and seroprevalence in health care workers. Nat Commun. 2020;11:5064. [CrossRef]
- 16. Garcia-Basterio AL, Moncunill G, Tortajada M, et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun. 2020;11:3500. [CrossRef]
- 17. Xu X, Sun J, Nie S, et al. Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China. Nat Med. 2020;26:1193-1195. [CrossRef]
- 18. Iversen K, Bundgaard H, Hasselbalch RB, et al. Risk of COVID-19 in health-care workers in Denmark: An observational cohort study. Lancet Infect Dis. 2020;20:1401-1408. [CrossRef]