Pradnya Shree DHOTRE, Adinath N. SURYAKAR, Rajashree B. BHOGADE

Oxidative stress in periodontitis

Periodontitis diş plaklarından köken alan bakteri ve ürünlerinin oluşturduğu sık görülen oral infeksiyonlardan bir tanesidir. Sigara içimi periodontitis için bir risk faktörü olduğu düşünülmektedir. Bununla birlikte sigara içiminin periodontitis gelişimi üzerindeki olumsuz etkileri tam olarak açıklığa kavuşturulamamıştır. Bu nedenle bu çalışmada sigara içimi ile serbest radikaller ve antiok- sidan düzeyleri açısından periodontitis arasındaki ilişkiyi araştırmak amacıyla planlandı. Çalışmaya toplam olarak 75 olgu dahil edildi. Bunlar, 25 sağlıklı kontrol, 25 sigara içmeyen periodontitisli hasta ve 25 sigara içen periodontitisli hastalardı. Tüm olgular serum lipid peroksit, nitrik oksit ve süperoksit dismutaz, toplam antioksidan kapasite ile glutatyon peroksidaz gibi antioksidanlar açısından tarandı. Periodontitisi bulunan her iki hasta grubunda serum lipid peroksit ve nitrik oksit önemli artış saptanırken se- rum süperoksit dismutaz, glutatyon peroksidaz ve toplam antioksidan kapasitesi azalma gözlenmiştir. Bununda ötesinde, oksidan düzeyleri anlamlı düzeyde yüksek bulundu ve antioksidan düzeyleri sigara içen hastalarda içmeyenlere olgulara göre anlamlı olarak düşük olduğu fark edildi. Böylece, sigara periodontitis oksidatif yükünü artırmada önemli bir rol oynar.

Periyodontisde oksidatif stres

Periodontitis is one of the most common oral infections induced by bacteria and bacterial products of dental plaque. Cigarette smoking is considered to be a risk factor for periodontitis. However, the exact mechanism by which smoking exerts its deleterious effects on periodontium remains unclear. Therefore the present study was planned to evaluate the relationship between cigarette smoking and periodontal damage in terms of the levels of free radicals and antioxidants. A total of 75 subjects were included in the study. Out of these, 25 were healthy controls, 25 were nonsmoker periodontitis patients and 25 were smoker periodontitis patients. All subjects were screened for serum lipid peroxide, nitric oxide and antioxidants such as superoxide dismutase, glu- tathione peroxidase along with total antioxidant capacity. A significant increase in serum lipid peroxide and nitric oxide with a corresponding decrease in serum superoxide dismutase, glutathione peroxidase and total antioxidant capacity was observed in both groups of periodontitis patients. Further, it was noticed that the oxidant levels were significantly higher and antioxidants were significantly lower in smoker patients than non-smoker patients. Thus, smoking plays a pivotal role in enhancing oxidative burden in periodontitis.

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