The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies

The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies

The PI3K/Akt/mTOR signalling pathway plays a crucial role in several biological processes, including cell proliferation, survival, and apoptosis, as well as regulates numerous signalling pathways, including JNK, NF-?B, and ERK pathways. The recent proliferation of signal transduction studies in neurological and cardiovascular diseases/injuries sheds light on Akt-dependent pathogenesis. The downregulation of the Akt signalling pathway 24 hours post-injury prevents neurogenesis and promotes the progression of severe secondary injuries, including neuroinflammation, scar formation, and neuronal and glial necrosis, following traumatic brain and spinal cord injury, suggesting designing therapeutic approaches within a 24-hour window postinjury. Similarly, the downregulation of the Akt signalling pathway in myocardial infarction lowers cardiovascular protection, limits neurovascularization, and inhibits cell survival. Following myocarditis, the Akt signalling network is upregulated, leading to aggravated inflammation, and increased myocardial damage. Also, the upregulation of the PI3K/Akt/mTOR pathway in chordoma promotes tumor progression and invasion, leading to neuronal damage and impaired physiological functions. Future therapeutics that target the aberrant expression of key players in the PI3K/Akt/mTOR signalling pathway present a promising approach to treating several neurological and cardiovascular pathologies. This narrative review discusses the role of PI3K/Akt/mTOR signalling pathway in traumatic central nervous system injuries (brain and spinal cord), cardiac injury (myocardial infarction), inflammatory disease (myocarditis), and rare neurological cancer (chordoma) along with therapeutic targets that are known to prevent worsened outcomes and promote recovery following those conditions.

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European Journal of Biology-Cover
  • ISSN: 2602-2575
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 1940
  • Yayıncı: İstanbul Üniversitesi Yayınevi
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Impact of Toxic Heavy Metals and Their Concentration in Zygophyllum Species, Mentha longifolia, and Thymus vulgaris Traditional Medicinal Plants Consumed in Setif-Algeria

Djarmounı MERIEM, Ilhem SEKIA, Djamila AMENİ, Tassadit IKESSOULEN, Abderrahmane BAGHIANI

Morphological and Biochemical Investigation of the Protective Effects of Panax ginseng on Methotrexate-Induced Testicular Damage

Fatma Bedia KARAKAYA-ÇİMEN, Caglar MACİT, Güzin Göksun SİVAS, Tuğba TUNALI-AKBAY, Göksel ŞENER, Feriha ERCAN

Anti-Bacterial, Anti-Mycobacterial and Anti-Fungal Properties of Punica granatum as Natural Dye

Pınar GÜNER, Tülin AŞKUN

The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies

Akshat MODİ, Aahmad MAHOON, Dharmeshkumar MODİ

The Use of Plant Steroids in Viral Disease Treatments: Current Status and Future Perspectives

Pınar OBAKAN YERLİKAYA, Elif Damla ARISAN, Leila MEHDİZADEHTAPEH, Pinar UYSAL-ONGANER, Ajda GÜRKAN