Toll Bezleri Resptörleri

Kalıp tanıma reseptörleri bakteriyel komponentlerin varlığını saptar ve invaze mikroorganizmaların eleminasyonu için oluşan yanıta aracılık eder. Bu çok eski evrimsel bakteriyel tanıma sistemi Drosophila immun sisteminde de saptanmış ve Toll sinyal yolu olarak adlandırılmıştır. Yapılan çalışmalar Drosophila Toll’unun homoloğu olan memeli Toll Benzeri Reseptörleri’nin yangısal cevabın uyarılmasında anahtar moleküller olduklarını göstermiştir.

Anahtar Kelimeler:

Etlik Veterinerlik Mikrobıyoloji Dergisi, Toll Bezleri, Reseptör, Hamit Kaan MÜŞTAK, Ömer M. ESENDAL, 2007

Toll Like Receptors

The pattern recognition receptors sense the presence of bacterial components and mediate responses for the elimination of invading microorganisms. This evolutionary ancient bacterial recognition system is found even in the Drosophila immune response, so called Toll signaling pathway. Recent studies revealed that mammalian Toll Like Reseptors, homologues of Drosophila Toll, are key molecules for recognizing bacterial components to evoke inflammatory response.

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