Ahmet SİPAHİOĞLU, Hamdi GİRGİN, Aysel ERGÜN, Reinhard FUHR

Tavukların Marek ve Loukosis Hastalıklarının Araştırılması ve Marek Hastalığına Karşı Etkin bir Aşı Hazırlama

Bu araştırma Türkiye'de MD ve LL'nin aranması, bu hastalıkların klinik, serolojik ve histopatolijik ayırımı ve Marek hastalığına karşı bir aşı hazırlamak için yapıldı. Marek hastalığının akut formu sadece kasaplık piliçlerde görüldü; buna karşın yumurtacı tavuklarda hastalığın kronik formuna rastlanıldı. Beyaz ırkların hastalığa daha alıngan oldukları , kırmızı ırkların örneğin Golden Commet'lerin en düşük alınganlık gösterdikleri saptandı. Hastalıktan şüpheli 417 hayvandan 1015 organ ve doku parçası alındı ve bunlar histopatolojik olarak incelendi; 240 hayvanda MD, 3 hayvanda da LL bulundu-. Bu materyallerde LL ve MD hücre kompozisyonlarına, göre karşılaştırıldı. LL tümörlerinde bir örnek büyük lenfoid hücreler (blast hücreler), buna karşın MD' de proliferatif lazyonlarda anizomorfik ve pleomorfik hücreler özellikle, çeşitli büyüklükte lenfoid hücreler, retikuler hücreler ve plasma hücreleri görüldü. MD'de ayrıpa heterofil granulositler ve fibrositik hücreler de dikkati çekti.Marek hastalığına karşı HVT-FC 126 aşı suşu kUllanılarak bir aşı yapıldı. Laboratuvar koşullarında bağışıklık oranı % 76,9 bulundu. MD'nin serolajik teşhisi için 2134 tavuk serum u yoklan-. dı. AGP testlerinde ·MD yönünden % 59,2 olumlu sonuç alındı.

Anahtar Kelimeler:

Marek, Tavuk, Loukosis, Marek Aşı, 1977, 1978, Ahmet SİPAHİOĞLU, Hamdi GİRGİN, Aysel ERGÜN, Reinhard FUHR

Differentiation between Marek's disease and leukosis among laying hens, its distribution curve and preparation of vaccine against Marek's disease

Ahmet Sipahioğlu; Harndi Girgin; Aysel Ergün, Reinhard Fuht, Etlik Veteriner Kontrol ve Araştırma Enstitüsü Ankara. This study was carried out in order to recognize the existence of Marek's disease and leukosis, its clinical, seralogisal and histopathological differentiation and the production of vaccine against Marek's disease in Turkey. Marek's disease in its acute form was observed in broilers Only whereas laying hens showed the· chronical form of the disease. White hens were more susceptible to the disease whereas red . races such as Golden Commets showed the lowest susceptibility. 1015 different organs from suspected hens were examined histopathologically and determined 240 . of . them as Marek's disease and 3 of the rest as lymphoid leukosis. LL and MD were compared with relate· to cellular compositian in these materials. LL tumors showed a uniform, large lymphoid cells (blast cells) whereas the cells in MD were determined · in proliferative lesions as being a.nisomorphic and pleomorphic cells, especially various size of lymphoid cells, reticular cells and plasma cells; it is also noticed .somotimes heterophil granulocytes and fibrocytic cells.A vaccine against Marek's disease was -produced with HVT - FC 126 vaccine strain. Serological rate of immunity was 76,9 % under the laboratory conditions. 2134 sera of hens. were exkamined serologically for 1 h ··) diagnosis of Marek's disease. İn the agar - gel precipitnti.on tests 59,2 % of hens sefa were positive for Marek's di.sease.

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