SAD B19'un Türkiye'de Hedef Dışı Türlerdeki Zararsızlık Testleri

SAD B 19 canlı modifiye virus suşunun, köpeklerin ağız yoluyla aşılanması için güvenirliği Türkiye'de iki ana bait alıcısında degerlendirilmiştir: bunlar evecil kedi ve karga vb. SAD B ı 9 aşı suşuının oral uygulamaclHn soıırcı evcil kediler ve saksağanlar için tamamen zararsız olduğu gösterilmiştir. Ayrıca toplam 81 adet yerel kemirgen (17 Mus musculus. 9 Rattus norvegicus. 13 Microtus epiroticus. 29 Apodemus sylvaticus ve 13 Apodemus agrarius) SAD B 19 attenue kuduz aşı virusu ile inokule edildi. Elde edilen sonuçlar ekstrem laboratuvar şartlarında oral uygulamalarda SAD B 19'un kalıntı seviyesinde patojenitesinin oldugunu teyit etmiştir. Bu kemirgenlerden toplam 5'i kuduzdan ölmüştür. Bununla birlikte bu rodentlerden 3 tane fare, aşı uygulamasından önce ether, ketamin hydrochloride ile anestelzi edilmiştir. Aşı virusu muhtemelen direkt olarak solunum yolu organlarına uygulanmış olabilir. Aşı virusunun aynı türdeki inokule hayvanlardan kontrol hayvanlarına nakli gözlenmemiştir. Bu da SAD B 19'un kemirgen populasyonlar içinde yayılım eğilimi olmadığını göstermektedir.

Anahtar Kelimeler:

SAD B19, Türkiye, Hedef Dışı Türler, Zararsızlık

Innocuity Tests Of SAD B19 in Turkish Nontarget Species

The safety of tl1e live modified vaccine virus SAD B 19 for oral vaccination of dogs was evaluated in the two main bait competitors in Turkey; domestic cats anel corvine species. It was shown that the SAD B19 vaccine virus was completely innocuous for domestic cats anel magpies (Pica pica) after oral application. Furthermore, a total of 81 local Turkish rodents ( 17 Mus musculus. 9 Rattus norvegicus. 13 Microtus epiroticus. 29 Apodemus sylvaticus anel 13 Apodemus agrarius) were inoculated orally with the attenuated rabies vaccine virus SAD B 19. The obtained results confirm that under laboratory conditions a residual pathogenicity of SAD B 19 for rodents exist when administered orally. A total of five rodents died from rabies. However. of these animals three M. musculus were anaesthetized with ether and ketamine-hydrochloride before vaccine administration. Partly. the vaccine virus was probably directly applied in the respiratory organs. Transmission ofvaccine virus from inoculated to control animals of the same species was not observed. indicating that there is no tendency for SAD B 19 to spread within rodent populations.

Keywords:

SAD B19, Türkiye, Hedef Dışı Türler, Zararsızlık,

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