Ayşe ÖĞÜTCÜ, Yavuz ULUSOY, Kevser KAHRAMAN, Meltem UZUNHİSARCIKLI, Fatma Gökçe UZUN, Hakkı TAŞTAN

Metil Parathion’un Sıçanların İnce Bağırsak Dokusu Üzerine Etkisi ve Vitamin C ve E’nin Koruyucu Rolü

Organofosfatlı bir insektisit olan metil parathion zirai mücadelede sıklıkla kullanılmakta ve zehirlenmelere neden olmak-tadır. Bu çalışmada, metil parathion (0.28 mg/kg gün), vitamin C (200 mg/kg gün)+vitamin E (200 mg/kg gün), vitamin C (200 mg/kg gün)+vitamin E (200 mg/kg gün)+metil parathion (0.28 mg/kg gün) erkek sıçanlara oral gavaj yoluyla verildi. Muameleden 4 hafta ve 7 hafta sonra sıçanların ince bağırsaklarındaki histopatolojik değişiklikler ışık mikroskobuyla incelendi. Metil parathion mu-amelesinden 4 ve 7 hafta sonra ince bağırsaklardaki villuslarda genişleme tespit edildi. Buna ilaveten 7. hafta sonunda bazı bölgelerde infiltrasyon gözlendi. Vitamin C+vitamin E+metil parathion muamemeli grupta da 4 ve 7 hafta sonra sıçanların ince bağırsakla-rında villusların yapısının bozulduğu gözlendi. Sonuç olarak düşük doz metil parathion sıçanların ince bağırsaklarında histopatolojik değişikliklere neden olmaktadır. Vitamin C ve vitamin E’nin, metil parathionun ince bağırsaklarda meydana getirdiği patolojik değişiklikleri önleyemediği tespit edildi.

Anahtar Kelimeler:

Etlik Veterinerlik Mikrobiyoloji Dergisi, Metil Parathion, İnce Bağırsak, Sıçan, Doku, Vitamin C, Vitamin A, Ayşe ÖĞÜTCÜ, Yavuz ULUSOY, Kevser KAHRAMAN, Meltem UZUNHİSARCIKLI, Fatma Gökçe UZUN, Hakkı TAŞTAN, 2007

Effect of Methyl Parathion on the Rat Small Intestine Tissue and Protective Role of Vitamın C and E

Methyl parathion, an organophosphorous insecticide, is widely used in agricultural control and causes poisoning. In the present study, methyl parathion (0.28 mg/kg day), vitamin C (200mg/kg day)+vitamin E(200 mg/kg day), vitamin C (200mg/kg day)+vitamin E (200 mg/kg day)+methyl parathion (0.28 mg/kg day) were given to male rats through gavage. Histopathological changes were investigated using light microscope 4 and 7 weeks after administration. After 4 and 7 weeks of methyl parathion exposure, dilatation was observed in intestinal villi. Addition to this, infiltration in some area was observed 7 weeks after. After 4 and 7 weeks of vitamins C+vitamin E+methyl parathion exposure, degenerative changes were detected in the intestinal villi. As a result, lower doses of methyl parathion caused histopathological changes in the rat small intestine. It’s determined that vi-tamin C and vitamin E haven’t prevented the pathological changes caused by methyl parathion in small intestine.

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