Melatonin, Etkileri ve Kullanım Alanları

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px} p.p2 {margin: 0.0px 0.0px 4.0px 19.0px; text-align: justify; line-height: 9.1px; font: 9.0px 'Times New Roman'} span.s1 {font: 12.0px 'Times New Roman'}  Melatonin günlük ve mevsimsel değişiklik gösterebilen pineal bezden salgılanan ve suprakiazmatik nukleus tarafından endojen ritmi düzenleyen bir hormondur. Günümüzde tıp ve veteriner hekimlikte ekzojen kullanım alanlarının genişlemesi bu hormonun önemini arttırmıştır. Hücresel kompartmanlara kolayca geçebilen bu hormon güçlü bir antioksidan özellik göstermekle beraber, sirkadyen ritmi düzenleyerek vücutta homeostazisi sağlar. Bağışıklık sistemi üzerine de olumlu etkileri bulunmaktadır. Bazı hayvan türlerinde de üreme siklusunu başlatıcı ya da inhibe edici etki gösterir. Yapılan çalışmalarla melatoninin antikanserojenik etkinliği ortaya koyulmuştur. Bu derlemede melatoninin biyokimyasal özellikleri ile kullanım alanları anlatılmaktadır.

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