Bor' un biyolojik önemi ve metabolizma üzerine etkileri

İnsan've hayvan 'organizmaları için esansiyel oldukları yeni belirlenmiş iz elementlerden birisi olan bor'un (B) kemik mineralizasyonunda etkin rol oynadığı, her ne kadar etki mekanizması bilinmiyorsa da testosteron ve (3-östradiol gibi steroid hormonların konsantrasyonunu artırabileceği ileri sürülmüştür. Günümüzde insan ve hayvanlarda çeşitli besinsel, metabolik, hormonal ve fizyolojik koşullarda bu elementin biyolojik önemi ve metabolizma üzerine etkilerine ilişkin çalışmalar devam etmektedir.

___

  • 1.Armstrong TA, Flowers WL, Spears, JW, Nielsen FH, 2002. Long-term effects of boron supplementation on reproductive characteristics and bone mechanical properties in gilts. J Anim Sci, 80: 154-161.
  • 2.Armstrong TA, Spears JW, Crenshaw TD, Nielsen FH, 2000.. Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites. J Nutr., 139: 2575-2581.
  • 3.Armstrong TA, Spears JW Lloyd KE, 2001. Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts. J Anim Set, 79: 1549-1556.
  • 4.Başoğlu A, Sevinç M, Güzelbektaş H, Civelek T, 2000. Short communication: Effect of borax on serum lipid profile in dogs. Online J Vet Res., 4:153-156.
  • 5.Beattie JH, Peace HS, 1993. The influence of a low-boron diet and boron supplementation on bo ne, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr., 69: 871-884.
  • 6.Benderdour M, Bui-Van T, Dicko A, Belleville F, 1998. In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol.,12: 2-7.
  • 7.Butterwick L, de Oude N, Raymond K, 1989. Safety assessment of boron in aquatic and terrestrial environments. Ecotoxicol Environ Safety., 17: 339-371.
  • 8.Dupre JN, Keenan MJ, Hegsted M, Brudevold AM, 1994. Effects of dietary boron in rats fed a vitamin D-deficienl diet. Environ Health Perspect., 1994; 102: 55-58. (Abstr.).
  • 9.Eren M, Uyanık F, Küçükersan S, 2002. Yumurta tavuğu yemlerine bor ilavesinin yumurta kalitesi ile serum Ca, P ve Mg düzeylerine etkisi. /. Ulusal Veteriner Biyokimya ve Klinik Biyokimya Kongre si. Ankara Üniversitesi Veteriner Fakültesi- Ankara, 21-22 Haziran., P16.
  • 10.Hail IH, Spielvogel BF, Griffin TS, Docks EL, Brotherton RJ, 1989. The effects of boron hypolipidemic agents on LDL and HDL receptor binding and related enzyme activities pf rat hepatocytes, aorta cells and human fibroblasts. Res Com Chem Path Pharm., 65: 297-317.
  • 11.Hegsted M, Keenan MJ, Siver F, Wozniak P, 1991. Effect of boron on vitamin D deficient rats. Biol Trace Elem Res., 28: 243-255.
  • 12.Hoffman DJ, Sanderson CJ, LeCaptain LJ, Cromatie E, Pendleton GW, 1991. Interactive effects of, boron, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings. Arch Environ Contam ToxicoL, 1991; 20:288-294.
  • 13.Hunt CD, 1989. Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick. Biol Trace Elem Res., 22: 201-220.
  • 14.Hunt CD, Herbel JL, 1991-92. Boron affects energy metabolism in the streptozotpcin-injected, vitamin D3-deprived rat. Magnes Trace Elem., 10: 374-386.
  • 15.Hunt CD, Herbel JL, 1991-92. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat. Magnes Trace Elem., 10: 387-408.
  • 16.Hunt CD, Herbel JL, Idso JP, 1994. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res., 9: 171-182. (Abstr.).
  • 17.King N, Odom TW, Sampson HW, Pardeu S, 1993. In ovo administration of boron or sodium aluminosilicate alters mineralization in the turkey. NutrRes., 13:77-85.
  • 18.Ku WW, Chapin, RE, Moseman RF, Brink RE, Pierce KD, Adams Y, 1991. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharm.,111:145-151.
  • 19.Kurtoğlu V, Kurtoğlu F, Coşkun B, 2001. Effects of boron supplementation of adequate and inadequate vitamin D3-containing diet on performance and serum biochemical characters of broiler chickens. Res Vet Sci., 11: 1.83-187. 20.Mc Dowell LR, 1992. Minerals In Animal and Human Nutrition. Academic Press Inc, London., pp 367-370.
  • 21.Moseman RF, 1994. Chemical disposition of boron in animals and humans. Environ Health Perspect., 102: 113-117 (Abstr.).
  • 22.Naghii MR, Samman S, 1997. The effect of boron on plasma testosterone and plasma lipids in rats. Nutr Res., 17:523-531.
  • 23.National Academies, 2001. Instute of Medicine Press Release, January 9.
  • 24.Nielsen FH, 1991. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J.,.5: 2661-2667.
  • 25.Nielsen FH, Hunt CD, Mu LM, Hunt JR, 1987. Effect of boron on mineral estrogen, and testosterone metabolism in postmenopausal women. FASEB J., 1: 394-397.
  • 26.Nielsen FH, Mullen LM, Gallagher SK, 1990. Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet. J Trace Elem Exp Med., 3: 45.-54.
  • 27.Nielsen FH, Schuler TR, 1992. Studies of the interaction between boron and calcium, and its modification by magnesium and potassium in rats. Effects on growth, blood variables, and bone mi neral composition. Biol Trace Elem Res., 35: 225-237 (Abstr).
  • 28.Nielsen FH, Schuler TR, Zimmerman TJ, Uthus, EO, 1988. Magnesium and methionine deprivation affect the response of rats to boron deprivation. Biol Trace Elem Res., 17: 91-107 (Abstr).
  • 29.Nielsen FH, Schuler TR, Zimmerman TJ, Uthus, oEO, 1988. Dietary magnesium, manganese and boron affect the response of rats to high dietary aluminium. Magnes., 7: 133-147.
  • 30.Penland JG, Eberhardt MJ, 1993. Effects of dietary boron and magnesium on brain function of mature male and female Long-Evans rats., J Trace Elem Exp Med., 6: 53-64.
  • 31.Qin X, Klandorf H, 1991. Effect of dietary boron supplementation on egg production, shell quality, and calcium metabolism in aged broiler breeder hens. Poultry ScL, 70: 2131-2138.
  • 32.Rossi AF, Bootwalla SM, Miles RD, 1990. Boron and riboflavin addition to broiler diets. Poultry ScL, 69:186 (Abstr).
  • 33.Rossi AF, Miles RD, Damron BL, Flunker LK, 1993. Effects of dietary boron supplementation on broilers. Poultry Sci, 72: 2124-2130.
  • 34.Sander JE, Dufour L, Wyatt RD, Bush PB, Page RK, 1991. Acute toxicity of boric acid and boron tissue residues after chronic exposure in broiler chickens. Avian Dis., 35: 745-749.
  • 35.Sisk, DB, Colvin BM, Merrill A, Bondadi K, Bowen JM, 1990. Experimental acute inorganic boron toxicosis in the goat: Effects on serum chemistry and CSF biogenic amines. Vet Hum Toxicol., 32:205-211.
  • 36.Tıbbıtts J, Sambol NC, Fike JR, Bauer WF, Stephen BK, 2000. Plasma pharmacokinetics and tissue biodistribution of boron following administration of a boronated porphyrin in dogs. j Pharm Sci, 89: 469-477. 37.Treinen KA, Chapin RE, 1991. Development of , testicular lesions in F344 rats after treatment with boric acid. Toxicol Appl Pharm., 107: 325-335.
  • 38.WHO, 1996. Trace Elements in Human Nutrition and Health: Boron. World Health Organization, Geneva, pp. 175-182.
  • 39.WHO, 1998. Boron. International Programme on Chemical Safety. Environmental Health Criteria 204. Ohio, USA. pp. 1-201.
  • 40.Wilson JH, Ruszler PL, 1996. Effects of dietary boron supplementation on laying hens. Br. Poult ScL, 37: 723-729.
  • 41.Wilson JH, Ruszler PL, 1997. Effects of boron on growing pullets. Biol Trace Elem Res., 56: 287-294.
  • 42.Wilson JH, Ruszler PL, 1998. Long term effects of boron on layer bone strength and production parameters. Br Poult Sci., 39: 11-15. (Abstr.).
  • 43.Yisheng B, Curtiss, H, 1998. Dietary boron enhances humoral immune responses. Tektran, United States Department of Agriculture. Agricultural Research Service. ,12-18.
  • 44.Zittle CA, 1951. Reaction of borate with substances of biological interest. Adv Enzymol., 12: 493-527. Alınmıştır: Kelly GS, 1997. Boron: A review of its nutritional interactions and therapeutic uses. Alt Med Rev., 2: 48-56.