Portal gastropatili hastalarda beta-2 mikroglobulin ve Helikobakter pilori ilişkisi

Amaç: Portal gastropatili hastalarda Helikobakter pilori ve beta-2 mikroglobulin ilişkisi net olarak tanımlanamamıştır. Bu çalışmada, Helikobakter pilori infeksiyonu olan ve olmayan hastaların serum ve doku beta-2 mikroglobulin düzeyleri ve bu düzeylerin portal gastropati ile ilişkisi incelenmiştir. Gereç ve Yöntem: Portal gastropatili 25 hasta ve 22 sağlıklı birey çalışmaya dahil edilmiştir. Mide biyopsileri incelenmiş, serum ve doku beta-2 mikroglobulin düzeyleri bakılmıştır. Bulgular: Yirmibeş portal hipertansif gastropatili olgunun 15'inde Helikobakter pilori infeksiyonu bulunmuştur. Bu 15 hastanı n 8'inde (%53.3) subendotelial beta-2 mikroglobulin artışı görülmüştür. Helikobakter pilori olmayan 10 hastanın 3'ünde (%30) subendotelial beta-2 mikroglobulin bulunmuştur. Fark istatistiksel olarak anlamlıdır (p

Anahtar Kelimeler:

Portal gastropati, Helikobakter pilori, beta-2 mikroglobulin

Beta-2 microglobulin levels and Helicobacter pylori in patients with portal gastropathy

Background/aims: The relationship between Helicobacter pylori and beta-2 microglobulin in patients with portal gastropathy has not been clearly defined yet. In this study, we aimed to compare the levels of serum and tissue beta-2 microglobulin in patients with and without Helicobacter pylori infection and to examine the relationship between levels of serum and tissue beta-2 microglobulin in patients with portal gastropathy. Methods: Twenty-five patients with portal gastropathy and 22 healthy persons were enrolled in this study. Gastric biopsies were histologically analyzed and tissue and serum beta-2 microglobulin levels were measured. Results: Helicobacter pylori infection was detected in 15 of 25 portal gastropathy patients. Subendothelial beta-2 microglobulin was detected in 8 of 15 (53.3%) portal hypertensive gastropathy patients with Helicobacter pylori. Subendothelial beta-2 microglobulin was detected in 3 of 10 (30%) portal hypertensive gastropathy patients without Helicobacter pylori. The difference between groups was statistically significant (p

Keywords:

Portal gastropathy, Helicobacter pylori, beta-2 microglobulin,

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