Obstrüktif Uyku Apne Sendromunda Tanı ve TedaviYöntemlerinde Güncel Yaklaşımlar

Obstrüktif Uyku Apnesi Sendromu (OUAS), üst solunum yollarının kısmen veya tamamen tıkanması ve oksijen desatürasyonu ilekarakterize karmaşık bir hastalıktır. OUAS prevalansı çok yüksektir ve tüm dünyada birçok insan bu rahatsızlıktan muzdariptir.OUAS’nın en yaygın sonuçları; üst hava yolu kollapsı, horlama ve solunumun durmasıdır. Teşhis ve tedavi temel bir öneme sahiptirve iş birliği yapan birçok uzmanlık alanı içermektedir. Hastalığın tanısında, gece boyunca yapılan polisomnografi (PSG) altınstandart olarak kabul edilmektedir. Tedavi seçenekleri, hastalığın ciddiyetine ve hastanın beklentilerine göre seçilmelidir. SürekliPozitif Havayolu Basıncı (CPAP; SPHB) tedavisi, oral aparey tedavisi ve mandibuler ilerletme cerrahisi yaygın olarak tercih edilentedavi yöntemleridir. SPHB tedavisi halen OUAS tedavisinde altın standart olarak kabul edilmektedir. Mandibuler ilerletme apareyi,SPHB tedavisi ile karşılaştırıldığında, hastalara kullanım kolaylığı sağladığı için klinisyenler ve hastalar tarafından tercihedilmektedir. Bu derlemenin amacı, hastaya uygun tedavi yönteminin seçilmesi ve uygulanması açısından OUAS ile ilgili mevcuttanı ve tedavi yöntemleri hakkında bilgi vermektir.

Current Approaches in Diagnosis and Treatment Modalities of Obstructive Sleep Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a complex disease characterized with partial or complete obstruction of the upperrespiratory tract and oxygen desaturation. The prevelance is high and a lot of people suffer from this disorder all around the world.The most common results of OSAS are upper airway collapse, snoring and respiratory arrest. Diagnosing and treating is offundamental importance, and involves multiple specialties cooperating. Full overnight polysomnography (PSG) is the gold standardfor diagnosis. The treatment options should be choosen according to the severity of the disease and patient’s expectations.Treatment options are divided into two as surgical and non-surgical options. Continuous Positive Airway Pressure (CPAP)treatment, oral appliance therapy and mandibular advancement surgery are the commonly preferred treatment modalities. CPAPtreatment is still accepted as the gold standard in treatment of OSAS. The mandibuler advancement appliance is preferred by theclinicians and the patients, due to their ease of use when compared with CPAP treatment. The aim of this review is to report currentdiagnosis and treatment methods related to OSAS in terms of choosing and applying the appropriate treatment method to thepatient.

___

  • 1. Attanasio, R., & Bailey, D. R. Dental management of sleep disorders. John Wiley & Sons, ABD. 2009, 3-31.
  • 2. Faber, J., Faber, C., & Faber, A. P. Obstructive sleep apnea in adults. Dental press J Orthod 2019; 24(3): 99- 109.
  • 3. Şahin L, Aşçioğlu M. Sleep and Regulation of Sleep. Journal of Health Sciences 2013; 22(1): 93–98.
  • 4. Kryger MH, Roth T, Dement WC. Principles and Practice of Sleep Medicine: Fifth Edition. 2010; 1–1723.
  • 5. AlRumaih HS, Baba NZ, AlShehri A, et al. Obstructive Sleep Apnea Management: An Overview of the Literature. J Adv Prosthodont 2018; 27(3): 260–265.
  • 6. Wang W, Di C, Mona S, et al. Tongue function: An underrecognized component in the treatment of obstructive sleep apnea with mandibular repositioning appliance. Can Respir J 2018: 1-7.
  • 7. Ngiam J, Balasubramaniam R, Darendeliler MA, et al . Clinical guidelines for oral appliance therapy in the treatment of snoring and obstructive sleep apnoea. Aust Dent J 2013; 58(4): 408–419.
  • 8. Society TT. Türk toraks derneğı̇ obstrüktı̇f uyku apne sendromu tani ve tedavı̇ uzlaşı raporu. Türk Toraks Dergisi 2012; 13: 66.
  • 9. Flemons WW, Buysse D, Redline S, et al. Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 22(5): 667–689.
  • 10. Cistulli PA, Sutherland K. Phenotyping obstructive sleep apnoea. Bringing precision to oral appliance therapy. J Oral Rehabil 2019; 46 (12): 1185–1192.
  • 11. Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000; 284(23): 3015–3021.
  • 12. Isono S. Obesity and obstructive sleep apnoea: Mechanisms for increased collapsibility of the passive pharyngeal airway. Respirology 2012; 17(1): 32–42.
  • 13. Kim AM, Keenan BT, Jackson N et al. Tongue fat and its relationship to obstructive sleep apnea. Sleep. 2014; 37(10): 1639-1648.
  • 14. Schwartz AR, Patil SP, Squier S, et al. Obesity and upper airway control during sleep. J Appl Physiol 2010; 108(2): 430-435.
  • 15. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008; 5(2): 136–143.
  • 16. Krishnan V, Dixon-Williams S, Thornton JD. Where There Is Smoke…There Is Sleep Apnea: Exploring the Relationship Between Smoking and Sleep Apnea. Chest 2014; 146(6): 1673–1680.
  • 17. Kasai T, Motwani SS, Elias RM, et al. Influence of rostral fluid shift on upper airway size and mucosal water content. J Clin Sleep Med 2014; 10(10): 1069–1074.
  • 18. Toraldo, D. M, Passali, D, Sanna, A. et al. Costeffectiveness strategies in OSAS management: a short review. Acta Otorhinolaryngol Ital 2007; 37(6): 447-453.
  • 19. Akkaya, A., Öztürk, Ö. Uyku Apne Sendromu Tanı Yöntemleri. Turkiye Klinikleri Pulmonary MedicineSpecial Topics 2008; 1(1), 50-57.
  • 20. Stuck BA, Maurer JT. Airway evaluation in obstructive sleep apnea. Sleep Med Rev 2008; 12(6): 411–436.
  • 21. Kurtulmuş H, Çötert, S, Tuncer, A. V. Obstrüktif uyku apnesinin tanısında lateral sefalometrik yaklaşım ve mandibular ilerletici splint ile tedavisi. EÜ Dişhek Fak Derg 2007; 28: 113-122.
  • 22. Yucel A, Unlu M, Haktanir A, et al. Evaluation of the upper airway cross-sectional area changes in different degrees of severity of obstructive sleep apnea syndrome: Cephalometric and dynamic CT study. AJNR Am J Neuroradiol 2005; 26(10): 2624–2629.
  • 23. Rose EC, Staats R, Lehner M, et al. Cephalometric analysis in patients with obstructive sleep apnea. Part I: Dignostic value. J Orofac Ortho 2002; 63(2): 143–153.
  • 24. Chen, H, Eckert, D. J, van der Stelt, et al. Phenotypes of responders to mandibular advancement device therapy in obstructive sleep apnea patients: A systematic review and meta-analysis. Sleep Med Rev 49; 2020: 101229.
  • 25. Guarda-Nardini, L., Manfredini, D., Mion, et al. Anatomically based outcome predictors of treatment for obstructive sleep apnea with intraoral splint devices: A systematic review of cephalometric studies. J Clin Sleep Med 11; 2015: 1327–1334.
  • 26. AL Chesson Jr, RA Ferber, JM Fry, et al. The indications for polysomnography and related procedures. Sleep 1997; 20(6): 423-487.
  • 27. Kapa S, Gami AS, Somer VK. Obstructive sleep apnea and hypertension: Interactions and clinical implications. Pack A.I. Sleep Apnea: Pathogenesis, Diagnosis and Treatment, 2nd Et., Philadelphia, Pennsylvania, 2011, 236–250.
  • 28. Roure N, Gomez S, Mediano O, et al. Daytime sleepiness and polysomnography in obstructive sleep apnea patients. Sleep Med 2008; 9(7): 727–731.
  • 29. Suen C, Ryan CM, Mubashir T, et al. Sleep Study and Oximetry Parameters for Predicting Postoperative Complications in Patients With OSA. Chest 2019; 155(4): 855–867.
  • 30. Kapoor M, Greenough G. Home sleep tests for obstructive sleep apnea (OSA). J Am Board Fam Med 2015; 28(4): 504–509.
  • 31. Masa JF, Corral J, Pereira R, et al. Effectiveness of home respiratory polygraphy for the diagnosis of sleep apnoea and hypopnoea syndrome. Thorax 2011; 66(7): 567–573.
  • 32. Kirsch DB. PRo: Sliding into home: Portable sleep testing is effective for diagnosis of obstructive sleep apnea. J Clin Sleep Med 2013; 9(1): 5–7.
  • 33. Obstructive sleep apnoea: Toolkit for commissioning and planning local NHS services in the UK. https://www.blf.org.uk/sites/default/files/OSA_Toolkit_2 015_BLF_0.pdf (17.10.2019)
  • 34. Isetta V, Navajas D, Montserrat JM, et al. Comparative assessment of several automatic CPAP devices’ responses: A bench test study. ERJ Open Res 2015; 1(1): 1–6.
  • 35. Shapiro GK, Shapiro CM. Factors that influence CPAP adherence: An overview. Sleep Breath 2010; 14(4): 323– 335.
  • 36. İşeri, H, Khalil, S. Obstrüktif Uyku Apne Sendromunda Diş Hekimliği Uygulamaları: Mandibuler İlerletme Aygıtı. Turkiye Klinikleri Pulmonary Medicine-Special Topics 2008, 1(1): 102-109.
  • 37. Sutherland K, Vanderveken OM, Tsuda H, et al. Oral appliance treatment for obstructive sleep apnea: An update. J Clin Sleep Med 2014; 10(2): 215–227.
  • 38. Mogell K, ABDSM, D, Blumenstock N, et al. Definition of an Effective Oral Appliance for the Treatment of Obstructive Sleep Apnea and Snoring: An Update for 2019. J Dent Sleep Med 2019; 6(3).
  • 39. Tingting X, Danming Y, Xin C. Non-surgical treatment of obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol 2018; 275(2): 335–346.
  • 40. Ng JH, Yow M. Oral Appliances in the Management of Obstructive Sleep Apnea. Sleep Med Clin 2019; 14(1): 109–118.
  • 41. Brunzini A, Gracco A, Mazzoli A, et al. Preliminary simulation model toward the study of the effects caused by different mandibular advancement devices in OSAS treatment. Comput Methods in Biomech and Biomed Engin 2018; 21(13): 693–702.
  • 42. Sutherland K, Chan ASL, Cistulli PA. Three-dimensional assessment of anatomical balance and oral appliance treatment outcome in obstructive sleep apnoea. Sleep Breath 2016; 20(3): 903–910.
  • 43. Epstein LJ, Kristo D, Strollo PJ, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009; 5(3): 263–276.
  • 44. Mayoral P, Lagravère MO, Míguez-Contreras M, et al. Antero-posterior mandibular position at different vertical levels for mandibular advancing device design. BMC Oral Health 2019; 19(1): 1–8.
  • 45. Chan ASL, Sutherland K, Schwab RJ, et al. The effect of mandibular advancement on upper airway structure in obstructive sleep apnoea. Thorax 2010; 65(8): 726–732.
  • 46. Watanabe T, Isono S, Tanaka A, et al. Contribution of body habitus and craniofacial characteristics to segmental closing pressures of the passive pharynx in patients with sleep-disordered breathing. Am J Respir Crit Care Med 2002; 165(2): 260–265.
  • 47. Schell TG. Avoiding and Managing Oral Appliance Therapy Side Effects. Sleep Med Clinics 2018; 13(4): 503–512.
  • 48. Sheats RD, Schell TG, Blanton AO,et al. Management of Side Effects of Oral Appliance Therapy for SleepDisordered Breathing. J Dent Sleep Med 2017; 04(04): 111–125.
  • 49. Ferguson KA, Cartwright R, Rogers R, et al. Oral appliances for snoring and obstructive sleep apnea: a review. Sleep 2006; 29(2): 244–262.
  • 50. Dieltjens M, Verbruggen AE, Braem MJ, et al. Determinants of objective compliance during oral appliance therapy in patients with sleep-disordered breathing: A prospective clinical trial. JAMA Otolaryngol Head Neck Surg 2015; 141(10): 894–900.
  • 51. Almeida FR, Parker JA, Hodges JS, et al. Effect of a titration polysomnogram on treatment success with a mandibular repositioning appliance. J Clin Sleep Med 2009; 5(3): 198–204.
  • 52. Dort L, Remmers J. A combination appliance for obstructive sleep apnea: The effectiveness of mandibular advancement and tongue retention. J Clin Sleep Med 2012; 8(3): 265–269.
  • 53. Kemaloğlu, Y. Obstrüktif Uyku Apne Sendromunda Cerrahi Yaklaşımlar. Turkiye Klinikleri Pulmonary Medicine-Special Topics 2008, 1(1): 110-119.
  • 54. Caples S. M, Rowley J. A, Prinsell J. R, et al. Surgical modifications of the upper airway for obstructive sleep apnea in adults: a systematic review and metaanalysis. Sleep 2010; 33(10): 1396-1407.
  • 55. Woodson BT. Nasal and palatal surgery for obstructive sleep apnea syndrome. Oral Maxillofac Surg Clin North Am 2002; 14(3): 365–369.
  • 56. Woodson BT, Toohill RJ. Transpalatal advancement pharyngoplasty for obstructive sleep apnea. Laryngoscope 1993; 103(3): 269 – 276
  • 57. Woodson BT. Retropalatal airway characteristics in uvulopalatopharyngoplasty compared with transpalatal advancement pharyngoplasty. Laryngoscope 1997; 107(6): 735–740.
  • 58. Hofauer B, Knopf A, Karl J, et al. Sonographic evaluation of anatomic landmarks in patients with obstructive sleep apnea. HNO 2019; 67(9): 685–689.
  • 59. Brown TM, Coleman J, Friedman L,et al. Practice Parameters for the Use of Continuous and Bilevel Positive Airway Pressure Devices to Treat Adult Patients With Sleep-Related Breathing Disorders. Sleep 2006; 29(3): 375–380.
  • 60. Keyf F, Burduroğlu D, Fırat Güven S, et al. Alternative technique to transfer jaw relations for custom mandibular advancement devices: A case report. Cranio 2019; 37(6): 395–399.
  • 61. Sakamoto Y, Furuhashi A, Komori E, et al. The most effective amount of forward movement for oral appliances for obstructive sleep apnea: A systematic review. Int J Environ Res Public Health 2019; 16(18): 1– 11.
  • 62. Alessandri-Bonetti A, Bortolotti F, Moreno-Hay I, et al. Effects of mandibular advancement device for obstructive sleep apnea on temporomandibular disorders: A systematic review and meta-analysis. Sleep Med Rev 2019; 48: 101211.
  • 63. Dieltjens, Marijke, Olivier M. Vanderveken. Oral Appliances in Obstructive Sleep Apnea. Healthcare 2019; 7(4); 141.
  • 64. Acar M, Cingi C, Sakallioglu O, et al. The effects of mometasone furoate and desloratadine in obstructive sleep apnea syndrome patients with allergic rhinitis. Am J Rhinol Allergy 2013; 27(4): 113-116.
  • 65. Pengo MF, Xiao S, Ratneswaran C, et al. Randomised sham-controlled trial of transcutaneous electrical stimulation in obstructive sleep apnoea. Thorax 2016; 71(10): 923–931.