VELİ ÖZGEN ÖZTÜRK, SEMA BECERİK, Harika ATMACA, GÜLNUR EMİNGİL

Farklı Periodontal Hastalıkta Dişeti Oluğu Sıvısı Kemik Yapım Ve Yıkım Biyomarkırlarının Karşılaştırılması

Amaç: Yaşlı bireylerde yaşla birlikte kemik metabolizmasında değişiklikler görülebilir. Araştırmamızın amacı farklı periodontal hastalığa sahip yaşlı bireylerde dişeti oluğu sıvısı (DOS) kemik yapım ve yıkım seviyelerinin karşılaştırılmasıdır. Yöntem: 65 yaş üstü, sistemik sağlıklı toplam 39 birey (periodontal sağlıklı (n=16), gingivitis (n=13) ve kronik periodontitisli (n=10) dahil edildi. Klinik ölçümlerde sondalanan cep derinliği (SCD), klinik ataşman seviyesi (KAS), sondalamada kanama (SK) ve plak indeksi (Pİ) kaydedildi. DOS örneklerinde kemik markırları alkalen fosfataz (ALP), osteokalsin (OK), osteopontin (OPN), osteoprotegerin (OPG) ve paratiroid hormon (PTH) seviyeleri enzyme-linked immunosorbent assay (ELISA) yöntemi ile analiz edildi. Elde edilen veriler non-parametrik testler ile değerlendirildi. Bulgular: Çalışma grupları arasında DOS ALP, OK, OPN, OPG ve PTH seviyelerinde fark bulunmadı (p>0.05). DOS ALP seviyesi, SCD ve KAS klinik parametreleriyle pozitif korelasyon gösterdi (p

Comparison Of Bone Turnover Markers In Gingival Crevicular Fluid Of Elderly Individuals With Different Periodontal Diseases

Objectives: Elderly individuals may exhibit alterated bone metabolism due to aging. The purpose of this study was to investigate bone formation and resorption levels in gingival crevicular fluid (GCF) of elderly subjects with different periodontal diseases. Methods: This study included 39 systemically healthy elderly participants aged > 65 years, including 10 with chronic periodontitis, 13 with gingivitis and 16 with healthy periodontium. Clinical periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PI) were recorded. GCF alkaline phosphatase (ALP), osteocalcin (OC), osteopontin (OPN), osteoprotegerin (OPG), and parathyroid hormone (PTH) were analyzed using enzyme-linked immunosorbent assay (ELISA). Statistical tests were performed using non-parametric methods. Results: There were no significant differences in GCF ALP, OC, OPN, OPG and PTH levels among the study groups (p>0.05). Moreover, ALP levels in GCF were positively correlated with site-specific clinical parameters including PD and CAL. Conclusion: Within the limitations of the present study, it may be concluded that investigated markers were able to detected in GCF however they may not play a role as bone turnover biomarkers in elderly individuals with different periodontal diseases

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