Enver VARDAR, ENVER İLHAN, Özgül ÖZGÜDER, Hakan POSTACI, Hayati ŞENGÜDER

Angiomatoid (Malign) fibröz histiositom: Olgu sunumu

Sağ uyluğun deri ve subkutan dokusuna ait bölgede angiomatoid (malign) fibröz histiositom tanısı alan 17 yaşındaki erkek olgu sunulmaktadır. Kitle klinik olarak, son 2 ayda hızlı büyüme öyküsü gösteren subkutan nodül şeklinde ortaya çıktı. Mikroskopik incelemede spesifik olarak kanla dolu doku boşlukları, kapillerden zengin stromada histiosit benzeri ve fibroblast benzeri hücrelerin proliferasyonu vardı. İmmünohistokimyasal olarak tümör hücreleri vimentin, CD 68 ve CD 34 için immunoreaktif olup, faktör VIII ilişkili antijen, desmin, düz kas aktini ve S-100 protein için negatif idi. Bu lezyonu lenf düğümünün metastatik lezyonlarından ve mezenkimal kökenli bazı subkutan malignitelerinden ayırt etmenin önemli olması nedeniyle sunulmaya uygun görüldü.

Anahtar Kelimeler:

Histiositoma, fibröz, Erkek, Ergenlik, Tanı, ayırıcı, Neoplazmlar, bağ dokusu ve yumuşak doku

Angiomatoid (Malignant) fibrous histiocytoma: Case report

We present a case of angiomatoid (malignant) fibrous histiocytoma of the skin and subcutaneous tissue on the right thigh of a 17-year-old man. The mass appeared clinically as a subcutaneous nodule with history of rapid growth within two months. Microscopically, there were a unique formation of blood-filled tissue spaces and proliferation of histiocyte-like and fibroblast-like cells in a capillary-rich stroma. Immunohistochemically the tumor cells were immunoreactive for vimentin, CD68, and CD34 and were negative for factor VIII-related antigen, desmin, smooth muscle actin, and S-100 protein. The importance of distinguishing this lesion from metastatic malignancies of lymph node and some subcutaneous malignancies of mesenchymal origin is emphasized.

Keywords:

Histiocytoma, Fibrous, Male, Adolescence, Diagnosis, Differential, Neoplasms, Connective and Soft Tissue,

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