Does Suppression of Tsh Affect The Mean Platelet Volume? Retrospective Case Control Study

There have been reports that the mean platelet volume changes in the way of increasing or decreasing in inflammatory diseases. We also wanted to investigate whether there is such a change in the mean platelet volume in thyroid diseases. The data of 1410 patients admitted to the endocrine outpatient clinic were reviewed retrospectively. Age, sex, thyroid disease diagnoses, TSH(μIU/ml), fT3(pg/ml), fT4(ng/dl), MPV(fl) values were recorded. The patients were divided into three groups according to TSH levels and their diagnosis This study included 1410 patients who were admitted to our endocrine outpatient clinic with a preliminary diagnosis of thyroid. 75.2% of the patients were female and 24.8% were male. The mean age of all patients was 47.87. The mean and standard deviation value of MPV(fl) was 7.49±1.25. We divided the patients into 3 according to their TSH levels: those with TSH values less than 0.35 μIU/ml, those with TSH values 0.35-4.94 μIU/ml and TSH values 4.94 μIU/ml ' greater than. There was no significant correlation between MPV and TSH (p=0.19). At the subgroups according to the diagnosis; (subacute thyroiditis, Graves disease, toxic adenoma, toxic multinodular goiter, hypothyroidism, tsh suppression in pregnancy, thyroid cancer, euthyroidism, suppressed TSH due to excessive drug use) there was no significant correlation between MPV and TSH (p=0.11, p=0.56, p=0.50, p=0.06, p=0.14, p=0.53, p=0.33, p=0.30, p=0.91 respectively). Is MPV a biomarker or can it play a role in thyroid diseases? According to our study, MPV is not considered as a suitable biomarker for thyroid diseases.

PDF

___

1. 1-Shahid MA, Sharma S. Physiology, Thyroid Hormone. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2019; 2019 Mar 23.

2. 2-Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm 2019; 2019: 9213074.

3. Ma Y, Zong D, Zhan Z, et al. Feasibility of mean platelet volume as a biomarker for chronic obstructive pulmonary disease: A systematic review and meta-analysis. J Int Med Res 2019; 27: 300060519887886.

4. Korkmaz S. Mean platelet volume and platelet distribution width levels in patients with mild psoriasis vulgaris with metabolic syndrome. Postepy Dermatol Alergol 2018; 35: 367-371.

5. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14: 28-32.

6. Büyükaslan H, Asoğlu M. Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder. Neuropsychiatr Dis Treat 2019; 15: 2879-2884.

7. Yildiz S, Eker E, Ozturk M, Alay M. A comparison of haemogram parameters of patients with thyroid papillary cancer and nodular goiter in Van, Turkey. J Pak Med Assoc 2019; 69: 1642-1646.

8. Yu YJ, Li N, Yun ZY, et al. Preoperative mean platelet volume and platelet distribution associated with thyroid cancer. Neoplasma 2017; 64: 594-598.

9. Wen W, Wu P, Li J, Wang H, Sun J, Chen H. Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer. J Transl Med 2018; 16: 261.

10. Dincel O, Bayraktar C. Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma. https://www.ncbi.nlm.nih.gov/pubmed/2831941 0. Bratisl Lek Listy 2017; 118: 153-155.

11. Yaylaci S, Tosun O, Sahin O, et al. Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. Asian Pac J Cancer Prev 2016; 17: 2321-2323.

12. Erdogan Yucel E, Demiral Sezer S. Relationship Between the Neutrophil to Lymphocyte Ratio and the Presence and Size of Thyroid Nodules. Cureus 2019; 11: e3866.

13. Lippi G, Danese E, Montagnana M, Nouvenne A, Meschi T, Borghi L. Mean platelet volume is significantly associated with serum levels of thyroid-stimulating hormone in a cohort of older euthyroid subjects. Endocr Res 2015; 40: 227-230.

14. Panzer S, Haubenstock A, Minar E. Platelets in hyperthyroidism: studies on platelet counts, mean platelet volume, 111-indium-labeled platelet kinetics, and platelet-associated immunoglobulins G and M. J Clin Endocrinol Metab 1990; 70: 491- 496.

15. Bagir GS, Haydardedeoglu FE, Bakiner OS, Bozkirli E, Ertorer ME. Mean platelet volume in Graves’ disease: A sign of hypermetabolism rather than autoimmunity? Pak J Med Sci 2017; 33: 871-875.