Sermin ALGU, Feray Ferda SENOL, Seda UGRAS, Fatih ESMER, Mehmet Akif KARA, Pınar EKİCİ, Oguz OZCELİK

Investigation of Irisin Level in Brucella Patients

This study aimed to determine whether the changes in the metabolism of Brucella patients affect the irisin hormone. Also, it is aimed to investigate the relationships between other laboratory findings used in the diagnosis of brucellosis patients and the irisin hormone. 160 persons (80 brucellosis, 80 controls) were included in this study. Blood was drawn from the people participating in the study following their overnight fast. Irisin level was measured by ELISA method, CRP and sedimentation levels were measured using autoanalysers and commercial kits. It was determined that the irisin level of Brucella patients was statistically significantly higher than the control group (p

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1. Baysal B. Brucella, (eds: Usyacelebi S.) Temel ve Klinik Mikrobiyoloji. Ankara Güneş Kitabevi Ltd. Şti. 1999; 571-577.

2. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006; 6: 91–99.

3. Black TF. Brucellosis. In: Cohen J, Powderly WG, editors. Infectious diseases. 2nd ed., St. Louis: Mosby; 2004; 1665–1667.

4. Doganay M, Alp ME. Bruselloz. Eds: Wilke Topcu, Soyletir G, Doganay M Enfeksiyon hastalıkları ve mikrobiyoloji. Nobel Tıp Kitabevi. Cilt 1: Baskı 3; 2008; 897-909.

5. Yuce A, Cavus SA. Turkiye’de bruselloz: genel bakıs. Klimik derg 2006; 19: 87–97.

6. Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6th ed., Philadelphia: Churchill Livingstone; 2005; 2669– 72.

7. Gotuzzo E, Celillo E, Brucella. In: Gorbach SI, Bartlett JG, Blacklow NR, editors. Infectious diseases. Philadelphia: Harcourt Brace Jovanovich Inc; 1992; 1513-1518.

8. Hall WH. Brucellosis. In: Evans AS, Brachman PS, editors. Bacterial infections of humans. 2nd ed., New York: Plenum Publishing Corp; 1991; 133-151.

9. Pittman QJ. A neuro-endocrine-immune symphony. J Neuroendocrinol 2011; 23: 1296- 1297.

10. Petrovsky N. Towards a unified model of neuroendocrine-immune interaction. Immunol Cell Biol 2001; 79: 350–357.

11. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic disease. Endocrine 2018; 59: 260-274.

12. Atici E, Mogulkoc R, Baltaci AK, Menevse E. Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats. Horm Mol Biol Clin Investig 2017; 33: 54.

13. Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481: 463-468.

14. Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. Plos One 2013; 8: 60563.

15. Ugras S, Ozcelik O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turkish Bulletin of Hygiene and Experimental Biology 2020; 77: 227-232.

16. Ozcelik O, Algul S, Yilmaz B. Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon, and at night in young trained male subjects. Cell Moll Biol. 2018; 64: 130-133.

17. Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects.Biol Sport 2017; 34: 339-344.

18. Olt S, Ergenc H, Acikgoz SB. Predictive contribution of neutrophil/lymphocyte ratio in diagnosis of brucellosis. Biomed Res Int 2015; 2015: 210502.

19. Demir F, Karadeniz C, Ozdemir R, et al. Usefulness of neutrophil to lymphocyte ratio in prediction of coronary artery lesions in patients with Kawasaki disease. Balkan Med J 2015; 32: 371-376.

20. Uygur F, Tanriverdi H, Aktop Z, et al. The neutro- phil-to-lymphocyte ratio in patients with obstructive sleep apnoea syndrome and its relationship with cardiovascular disease. Heart Lung 2016; 45: 121-125.

21. Kucuk A, Erol MF, Senel S, et al. The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis. Korean J Intern Med 2016; 31: 386-391.

22. Atan D, Ikinciogullari A, Koseoglu S, et al. New predictive parameters of Bell’s palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 2015; 32: 167-170.

23. Yin X, Xiao Y, Li F, Qi S, Yin Z, Gao J. Prognostic role of neutrophil-to-lymphocyte ratio in prostate cancer: a sys- tematic review and metaanalysis. Medicine (Baltimore) 2016; 95: 2544.

24. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med 1986; 15: 557–564.

25. Sarac F, Buyukbese Sarsu S, Yeniocak S, et al. The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain. Emerg Med Int 2018; 2018: 3296535.

26. Gouveia MC, Vella JP, Cafeo FR, Affonso Fonseca FL, Bacci MR. Association between irisin and major chronic diseases: a review. Eur Rev Med Pharmacol Sci 2016; 20: 4072-4077.

27. Bashar SM, Samir El-Sherbeiny SM, Boraie MZ. Correlation between the blood level of irisin and the severity of acute myocardial infarction in exercise-trained rats J Basic Clin Physiol PharmacoL 2018; 30: 59-71