Serek TEKİN, MUHAMMED BATUR, Ufuk DÜZENLİ, ERBİL SEVEN, MUHAMMET DERDA ÖZER

Relationship Between Ocular Pseudoexfoliation and Sensorineural Hearing Loss

The purpose of this study is to evaluate the air and bone conductance rates in audiogram between healthy individuals and the patients having pseudoexfoliation (PEX). Patients with evidence of ocular PEX and controls were included in the study. Air conduction hearing thresholds (minimal perceptible sounds) were determined at frequencies of 250, 500, 1000, 2000, 4000, 6000, 8000 Hz and bone conduction hearing thresholds were determined at frequencies of 500, 1000, 2000, 4000 Hz for each ear. At these frequencies, air and bone conductance rates in audiogram were measured for patients with PEX and control group to analyze the relation between conductance rates and PEX cases. 86 participants were enrolled in this case-control study, in which 40 of them having PEX. The acquired results showed that the PEX group displayed significantly higher hearing tresholds in air conductance compared with control subjects a t frequencies of 250, 500, 1000, 2000, 4000 Hz, but not at frequencies of 6000, 8000 Hz. Similar results were obtained in bone conduction thresholds as well, in terms of the tendency of decreasing significance level between the groups in higher frequencies. In our study, we have shown that there is a statistically significant sensorineural hearing loss in PEX patients comparing age control subjects. These findings are more significant in lower frequencies, and the significance level is decreased toward the higher frequencies. Based on these findings, we speculate that endolymphatic pressure increase could have a role in the pathogenesis of PEX related sensorineural hearing loss.

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1. Henry JC, Krupin T, Schmitt M, Lauffer J, Miller E, Ewing MQ, et al. Long-term follow-up of pseudoexfoliation and the development of elevated intraocular pressure. Ophthalmology 1987; 94: 545-552.

2. Lindberg JG. Clinical investigations on depigmentation of the pupillary border and translucency of the iris in cases of senile cataract and in normal eyes in elderly persons. Acta ophthalmologica Supplement 1989; 190: 1.

3. Forsman E, Cantor RM, Lu A, Eriksson A, Fellman J, Järvelä I, et al. Exfoliation syndrome: prevalence and inheritance in a subisolate of the Finnish population. Acta Ophthalmologica Scandinavica 2007; 85: 500-507.

4. Schlötzer-Schrehardt UM, Koca MR, Naumann GO, Volkholz H. Pseudoexfoliation syndrome ocular manifestation of a systemic disorder? Archives of ophthalmology 1992; 110: 1752-1756.

5. Ritch R. Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. Journal of glaucoma 1994; 3: 176-177.

6. Shastri L, Vasavada A. Phacoemulsification in Indian eyes with pseudoexfoliation syndrome. Journal of Cataract & Refractive Surgery 2001; 27: 1629-1637.

7. Lim DJ. Functional structure of the organ of Corti: a review. Hearing research 1986; 22: 117- 146.

8. Turacli ME, Özdemir FA, Tekeli O, Gökcan K, Gerçeker M, Dürük K. Sensorineural hearing loss in pseudoexfoliation. Canadian journal of ophthalmology 2007; 42: 56-59.

9. Yazdani S, Tousi A, Pakravan M, Faghihi A-R. Sensorineural hearing loss in pseudoexfoliation syndrome. Ophthalmology 2008; 115: 425-429.

10. Shah A, Ganie R, Shah A, Rasid S, Dar I. Is There an Association between Pseudoexfoliation and Sensorineural Hearing Loss? A Case Control Study.

11. Strenzke N, Pauli-Magnus D, Meyer A, Brandt A, Maier H, Moser T. Update zur Physiologie und Pathophysiologie des innenohrs. HNO 2008; 56: 27-36.

12. Singham NV, Zahari M, Peyman M, Prepageran N, Subrayan V. Association between ocular pseudoexfoliation and sensorineural hearing loss. Journal of ophthalmology 2014; 2014.

13. Samarai V, Samarei R, Haghighi N, Jalili E. Sensory-neural hearing loss in pseudoexfoliation syndrome. International journal of ophthalmology 2012; 5: 393.

14. Cahill M, Early A, Stack S, Blayney A, Eustace P. Pseudoexfoliation and sensorineural hearing loss. Eye 2002; 16: 261-266.

15. Shaban RI, Asfour WM. Ocular pseudoexfoliation associated with hearing loss. Saudi Med J 2004; 25: 1254-1257.

16. Papadopoulos TA, Naxakis SS, Charalabopoulou M, Vathylakis I, Goumas PD, Gartaganis SP. Exfoliation syndrome related to sensorineural hearing loss. Clinical & experimental ophthalmology 2010; 38: 456-461.

17. Mazurek B, Stöver T, Haupt H, Gross J, Szczepek A. Pathogenesis and treatment of presbyacusis. Current status and future perspectives. Hno 2008; 56: 429-32, 34.

18. Ozkan BA, Yüksel N, Keskin G, Altintaş Ö, Karabaş V, Cağlar Y, et al. Homocysteine levels in plasma and sensorineural hearing loss in patients with pseudoexfoliation syndrome. European journal of ophthalmology 2006;16: 542-547.

19. Paliobei VP, Psillas GK, Mikropoulos DG, Haidich A-B, Constantinidis J, Konstas AG. Hearing evaluation in patients with exfoliative and primary open-angle glaucoma. Otolaryngology-- Head and Neck Surgery 2011; 145: 125-130.

20. Papadopoulos T, Charalabopoulou M, Vathylakis I, Goumas P, Gartaganis S, Naxakis S. Prevalence and severity of sensorineural hearing loss in patients with exfoliation syndrome. European review for medical and pharmacological sciences 2012; 16: 902-907.

21. Zojaji R, Alesheykh A, Sedaghat MR, Navia K, Baf MMF, Khaki M, et al. Pseudoexfoliation syndrome and sensorineural hearing loss. Iranian Journal of Otorhinolaryngology 2011; 23: 149.

22. Turgut B, Alpay HC, Kaya MK, Oger M, Celiker U, Yalcin S. The evaluation of vestibular functions in patients with pseudoexfoliation syndrome. European archives of oto-rhinolaryngology 2010; 267: 523-527