Comparison of Therapeutic Results of the Starting Time of Hyperbaric Oxygen Therapy in Sudden Sensorineural Hearing Loss

This study aimed to assess the impact of the hyperbaric oxygen (HBO) therapy starting time (early or late) on the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). A retrospective analysis examined 203 patients with ISSNHL between January 2014 and June 2018 at Van Training and Research Hospital. We divided the patients into two groups according to the HBO therapy starting time as follows: early HBO (n = 88) and late HBO (n = 115). The early HBO group demonstrated complete, partial, weak, and no recovery in 21 (23.9%), 15 (17.0%), 17 (19.3%), and 35 (39.8%) patients, respectively. The late HBO group demonstrated complete, partial, weak, and no recovery in 5 (4.3%), 9 (7.8%), 15 (13.0%), and 86 (74.8%) patients, respectively. In addition, 53 (60.2%) and 29 (25.2%) patients in the early and late HBO groups, respectively, responded to treatment, which was statistically significant (P < 0.05). Considering patients with severe and profound hearing loss only, we observed a statistically significant difference in response to treatment between the early and late HBO groups (P < 0.05). The study demonstrates that providing HBO therapy during the first 14 days of the treatment period contributed significantly to treatment success. Therefore, patients with severe and profound hearing loss can significantly benefit by starting HBO therapy at an early stage of the disease

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1. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngology-Head and Neck Surgery 2012; 146: 1-35.

2. Byl Jr FM. Sudden hearing loss: eight years' experience and suggested prognostic table. The Laryngoscope 1984; 94: 647-661.

3. Levie P, Desgain O, De Burbure C, Germonpré P, Monnoye J, Thill M, et al. Sudden hearing loss. B ENT 2007; 3: 33.

4. Kanzaki J, Inoue Y, Ogawa K, Fukuda S, Fukushima K, Gyo K, et al. Effect of single-drugtreatment on idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx 2003; 30: 123- 127.

5. Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Archives of otolaryngology (Chicago, Ill : 1960) 1980; 106: 772-776.

6. Lamm K, Lamm C, Arnold W. Effect of isobaric oxygen versus hyperbaric oxygen on the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Advances in oto-rhino-laryngology 1998; 54: 59-85.

7. Murphy-Lavoie H, Piper S, Moon RE, Legros T. Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc 2012; 39: 777-792.

8. İnanlı S, Polat Ş, Tutkun A, Batman Ç, Üneri C, Şehitoğlu M. Ani işitme kayıplı olgularımızda tedavi ve prognozun retrospektif analizi. Türk Otolaringoloji Arşivi. 2002;40(3):196-200.

9. Byl FM. Seventy‐six cases of presumed sudden hearing loss occurring in 1973: prognosis and incidence. The Laryngoscope 1977; 87: 817-825.

10. Filipo R, Attanasio G, Viccaro M, Russo FY, Mancini P, Rocco M, et al. Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss. Acta otolaryngologica 2012; 132: 475-481.

11. Moskowitz D, Lee K, Smith HW. Steroid use in idiopathic sudden sensorineural hearing loss. The Laryngoscope 1984; 94: 664-666.

12. Cvorovic L, Jovanovic MB, Milutinovic Z, Arsovic N, Djeric D. Randomized prospective trial of hyperbaric oxygen therapy and intratympanic steroid injection as salvage treatment of sudden sensorineural hearing loss. Otology & Neurotology 2013; 34: 1021-1026.

13. Yang C-H, Wu R-W, Hwang C-F. Comparison of intratympanic steroid injection, hyperbaric oxygen and combination therapy in refractory sudden sensorineural hearing loss. Otology & Neurotology 2013; 34: 1411-1416.

14. Horn CE, Himel HN, Selesnick SH. Hyperbaric oxygen therapy for sudden sensorineural hearing loss: a prospective trial of patients failing steroid and antiviral treatment. Otology & Neurotology 2005; 26: 882-889.

15. Alimoglu Y, Inci E, Edizer DT, Ozdilek A, Aslan M. Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid+ hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases. European Archives of Oto-Rhino-Laryngology 2011; 268: 1735-41.

16. Liu SC, Kang BH, Lee JC, et al. Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for OtoRhino-Laryngology & Cervico-Facial Surgery 2011; 36: 121-128.

17. Topuz E, Yigit O, Cinar U, Seven H. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss? European Archives of Oto-Rhino-Laryngology and Head & Neck 2004; 261: 393-396.

18. Fujimura T, Suzuki H, Shiomori T, Udaka T, Mori T. Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss. European archives of oto-rhino-laryngology 2007; 264: 861-866.

19. Yıldırım E, Özcan KM, Palalı M, Cetin MA, Ensari S, Dere H. Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 2015; 272: 23-28