Assessment of Pain Perception After Conventional Frenectomy With Application of Cold Atmospheric Plasma

Frenectomy is a surgical technique that purposes to remove the unusual frenum. There are a limited number of studies examining the effect of cold atmospheric plasma on periodontal tissues. The aim of this stud y was to investigate the effect of Cold Atmospheric Plasma (CAD) application on pain and discomfort in patients after conventional frenectomy operations. Eigthy-seven patients (38 male and 49 female, aged between 18-36 years) with mucogingival problems because of maxillary labial frenums were selected for this study. Patients were randomly divided into two groups: group 1(G1) frenectomy with conventional surgery and group 2(G2) frenectomy with conventional surgery+CAP. The frenum was held with a hemostat inserted to the depth of the vestibule and incision were placed on. After the triangular resected portion of the frenum was removed with the hemostat and wound were sutured. Conventional surgical technique was repeated for G2 and the surgical area was irradiated using CAP (kINPen 11). Visual Analog Scale (VAS) was used to rate postoperative degrees of pain and functional discomforts (chewing and speech) at 1st, 3rd, 7th and 10th days. VAS score for pain was significantly lower in the G2 group as compared to the G1 on 1st, 3th, 7th and 10th days. Similarly, when the chewing and speech VAS values are compared, the values in the G2 are lower than the G1 (p>0.05). According to these results, we can conclude that plasma reduces complications that may occur after frenectomy and these results may related to the positive effect of plasma on wound healing.

___

1. Chaubey KK, Arora VK, Thakur R, Narula IS. Perio-esthetic surgery: using LPF with frenectomy for prevention of scar. J Indian Soc Periodontol 2011; 15: 265–269.

2. Neiva TGG, Ferreira DCD, Maia BGF, Blatt M, Nogueira Filho GR, Tunes UR. Frenectomy technique associated with mastigatory mucosa graft: clinical case report. Rev Dental Press Periodontia Implantol 2008; 2: 31–36.

3. Díaz-Pizán ME, Lagravère MO, Villena R. Midline diastema and frenum morphology in the primary dentition. J Dent Child 2006; 26: 11-14.

4. Shetty K, Trajtenberg C, Patel C, Streckfus C. Maxillary frenectomy using a carbon dioxide laser in a pediatric patient: a casereport. Gen Dent 2008; 56: 60–63.

5. Gottsegen R. Frenum position and vestibule depth in relation to gingival health. Oral Surg 1954; 7: 1069-1072.

6. Miller PD Jr. The frenectomy combined with a laterally positioned pedicle graft; functional and aesthetic consideration. J Periodontol 1985; 56: 102-106.

7. Fiorotti RC, Bertolini MM, Nicola JH, Nicola EM. Early lingual frenectomy assisted by CO2 laser helps prevention and treatment of functional alterations caused by ankyloglossia. Int J Orofacial Myology 2004; 30: 64‑ 71.

8. Bullock N Jr. The use of the CO2 laser for lingual frenectomy and excisional biopsy. Compend Contin Educ Dent 1995; 16: 1118-1120.

9. Haytac MC, Ozcelik O. Evaluation of patient perceptions after frenectomy operations: A comparison of carbon dioxide laser and scalpel techniques. J Periodontol 2006; 77: 1815‑ 1819.

10. Laroussi M. Sterilization of contaminated matter with atmospheric pressureplasma. IEEE Transactions on Plasma Science 1996; 24: 1188- 1191.

11. Heinlin J, Zimmermann JL, Zeman F, et al. Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites. Wound Repair and Regeneration 2013; 21: 800-807.

12. Kleineidam B, Nokhbehsaim M, Deschner J, Wahl G. Effect of cold plasma on periodontal wound healing—an in vitro study. Clinical oral investigations 2019; 23: 1941-1950.

13. Küçük D, Savran L, Ercan UK, et al. Evaluation of efficacy of non-thermal atmospheric pressure plasma in treatment of periodontitis: a randomized controlled clinical trial. Clinical Oral Investigations 2020; 1-13.

14. Arndt S, Schmidt A, Karrer S, von Woedtke T. Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing. Clinical Plasma Medicine 2018; 9:24-33.

15. Matthews DC, McCulloch CAG. Evaluating patient perceptions as short-term outcomes of periodontal treatment: A comparison of surgical and non-surgical therapy. J Periodontol 1993; 64: 990-997.

16. Shibata Y, Hosaka M, Kawai H, Miyazaki T. Glow discharge plasma treatment of titanium plates enhances adhesion of osteoblast-like cells to the plates through the integrin-mediated mechanism. International Journal of Oral & Maxillofacial Implants 2002; 17.

17. Koban I, Holtfreter B, Hübner NO, et al. Antimicrobial efficacy of non-thermal plasma in comparison to chlorhexidine against dental biofilms on titanium discs in vitro–proof of principle experiment. Journal of clinical periodontology 2011; 38: 956-965.

18. Chen M, Zhang Y, Driver MS, Caruso AN, Yu Q, Wang Y. Surface modification of several dental substrates by non-thermal, atmospheric plasma brush. Dental Materials 2013; 29: 871-880.

19. Zhou X, Xiong Z, Cao Y, Lu X, Liu D. The antimicrobial activity of an atmospheric-pressure room-temperature plasma in a simulated rootcanal model infected with enterococcus faecalis. IEEE Transactions on Plasma Science 2010; 38: 3370-3374.

20. Wang G, Ye G, Yang X, et al. The Efficacy, Safety, Stability, and Mechanism of Tooth Whitening by a Cold Atmospheric Pressure Air Plasma Microjet Assisted With or Without Hydrogen Peroxide. IEEE Transactions on Plasma Science 2014; 42: 1623-1628.

21. Butchibabu K, Koppolu P, Mishra AP, Pandey R, Swapna LA, Uppada UK. Evaluation of patient perceptions after labial frenectomy procedure: A comparison of diode laser and scalpel techniques. Eur J Gen Dent 2014; 3: 129-133.

22. Bıçakcı H, Çapar İD, Genç S, İhtiyar A, Sütçü R. Influence of rotary instrumentation with continuous irrigation on pain and neuropeptide release levels: a randomized clinical trial. Journal of endodontics 2016; 42: 1613-1619.

23. Güzeldemir E. Pain assessment methods. Sendrom 1995; 7: 11-21.

24. Kahnberg KE, Thilander H. Healing of experimental excisional wounds in the rat palate: (I) Histological study of the interphase in wound healing after sharp dissection. International journal of oral surgery 1982; 11: 44-51.

25. Nakajima Y, Mukai K, Rahayu HSE, et al. Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, reepithelialization and wound contraction. Clinical Plasma Medicine 2014; 2: 28- 35.

26. Schmidt-Bleker A, Winter J, Iseni S, Dünnbier M, Weltmann KD, Reuter S. Reactive species output of a plasma jet with a shielding gas devicecombination of FTIR absorption spectroscopy and gas phase modelling. J Phys D: Appl Phys 2014; 47: 145201.

27. Bender CP, Hübner NO, Weltmann KD, Scharf C, Kramer A. Tissue tolerable plasma and polihexanide: are synergistic effects possible to promote healing 192 of chronic wounds? In vivo and in vitro results. In: Plasma for BioDecontamination, Medicine and Food Security: Springer 2012: 321-334.

28. Dobrynin D, Wu A, Kalghatgi S, et al. Live pig skin tissue and wound toxicity of cold plasma treatment. Plasma Med 2011; 1.

29. Malone‐Povolny MJ, Maloney SE, Schoenfisch MH. Nitric oxide therapy for diabetic wound healing. Advanced healthcare materials 2019; 8(12): 180121.

30. Isbary G, Morfill G, Schmidt HU, et al. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. British Journal of Dermatology 2010; 163: 78-82.

31. Moreau M, Orange N, Feuilloley MGJ. Nonthermal plasma technologies: new tools for biodecontamination. Biotechnology advances 2008; 26: 610-617.

32. Liu YCG, Lerner UH, Teng YTA. Cytokine responses against periodontal infection: protective and destructive roles. Periodontol 2000 2010; 52: 163-206.

33. Kalghatgi S, Friedman G, Fridman A, Clyne AM. Endothelial cell proliferation is enhanced by low dose non-thermal plasma through fibroblast growth factor-2 release. Ann Biomed Eng 2010; 38: 748-757.

34. Hirata T, Kishimoto T, Tsutsui C, Kanai T, Mori A. Healing burns using atmospheric pressure plasma irradiation. Japanese Journal of Applied Physics 2014; 53: 010302.

35. Haertel B, Eiden K, Deuter A, Wende K, von Woedtke T, Lindequist U. Differential effect of non-thermal atmospheric-pressure plasma on angiogenesis. Lett. Appl. NanoBioSci 2014; 3: 159-166.

36. Chatraie M, Torkama G, Khani M, Salehi H, Shokri B. In vivo study of non-invasive effects of non-thermal plasma in pressure ulcer treatment. Scientific reports 2018; 8: 1-11
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Preprocedural Platelet-To-Lymphocyte and PlateletTo-Neutrophile Ratios As The Predictors of Local Recurrence Following Ultrasound-Guided Microwave Ablation For Colorectal Cancer Liver Metastases

Serkan ARIBAL

Evaluation of Skin Prick Test Results In Patients With Atopic Dermatitis

Ömer KUTLU, Ahmet METİN

Self-Care Agency and Affecting Factors in Patients With Chronic Obstructive Pulmonary Disease

Züleyha KILIÇ, Songül GÖRİŞ

Surgeons Experience and Consistency To Determine Surgical Procedures For Hallux Valgus

Evrim SİRİN, Barış YILMAZ, Guzelali OZDEMİR, Erhan OKAY, Celaleddin BİLDİK, Dursun AK, Bülent EROL, Hasan Hilmi MURATLI

Comparison of Therapeutic Results of the Starting Time of Hyperbaric Oxygen Therapy in Sudden Sensorineural Hearing Loss

Yaser Said ÇETİN, Gülin Eergun TAŞDÖVEN

The Effect of Neuromuscular Electrical Stimulation Therapy On Stress Urinary Incontinence Recurrence: A Randomized Prospective Study

Erbil KARAMAN, Ali KOLUSARI, Şeyhmus KAPLAN

Does Cervical Length Predict the Successful Labor Induction in Term Nulliparous Women Who Had Unfavorable Cervix?

Gurcan TURKYILMAZ, Sebnem Erol TURKYILMAZ, Emircan ERTÜRK, Onur KARAASLAN

The Effect of Cachexia On Survival In Metastatic Gastric Cancer Patients Treated With Best Supportive Care

Ayşegül SAKİN, Mehmet Naci ALDEMİR

Gastrıc Intestınal Metaplasıa and Covıd 19 Infectıon

Mesut AYDIN, Ahmet cumhur DÜLGER, Serhat ÖZER, Yaren DİRİK, Sıddık KESKİN, Canan DEMİR

Fixed Orthodontic Treatment of a Patient With Skeletal Class II Malocclusion with Infrazygomatic Anchorage and En-Masse Retraction

Saadet Çınarsoy CİĞERİM, Seda KOTAN, Gönül DİNÇ