SEMA BAYKARA, MUHAMMED FATİH TABARA, SEVDA KORKMAZ, Murat ATMACA

Acute Dystonia Caused by Clomipramine: a Case Report

Drug-induced acute dystonia is a movement disorder that occurs most often with neuroleptics, though there are many drugs in its etiology. The exact mechanism of antidepressant-associated extrapyramidal side effects (EPS) is not known. However, hypotheses including inhibition of dopaminergic function in the nigrostriatal pathway, impaired balance between dopaminergic, serotonergic, noradrenergic or cholinergic activity, and serotonergic inhibition of dopaminergic functions in the striatum leading to extrapyramidal side effects have been suggested. The number of cases with acute dystonia during clomipramine use is low. We wish to draw attention to this rare side effect of clomipramine and to contribute to the literature by presenting a case of acute dystonia on the 5 th day of clomipramine treatment in a 19-year-old male patient.

Klomipraminin neden olduğu akut distoni: Bir olgu sunumu

İlaç kullanımıyla ortaya çıkan akut distoni, etiyolojisinde birçok ilacın olduğu ama en sık nöroleptiklerle ortaya çıkan bir hareket bozukluğudur. Antidepresan kullanımı ile ortaya çıkan ekstrapiramidal yan etkilerin oluş mekanizması tam olarak bilinmemektedir. Ancak, dopaminerjik fonksiyonların nigrostriatal yolakta inhibe edilmesi, dopaminerjik, serotonerjik, noradrenerjik veya kolinerjik aktivite arasındaki dengenin bozulması, striatumda dopaminerjik fonksiyonların serotonin tarafından inhibisyonunun ekstrapiramidal yan etkilere yol açması ileri sürülen hipotezlerdendir. Literatürde klomipramin kullanımı sonrasında akut distoni gelişen vaka sayısı nadirdir. Biz 19 yaşındaki erkek hastamızda klomipramin kullanımının 5. gününde ortaya çıkan akut distoni gelişimi olgusunu sunarak klomipraminin nadir görülen bu yan etkisine dikkat çekmek ve literatüre katkıda bulunmak istedik.

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