Treatment Management of Leptomeningeal and Brain Metastases as a First Reccurence Site in a Case with Germ Cell Testicular Tumor

Patients with testicular germ cell tumors (TGCT) usually presented with a testicular mass and retroperitoneal lymph nodes metastases, but brain and leptomeningeal metastases are rarely encountered in oncology practice. There are not any proven treatment options for relapsing TGCT with brain or leptomeningeal metastasis. We herein present a rare case of TGCT of brain and leptomeningeal metastasis as a first sign of recurrence with literature review.

Treatment Management of Leptomeningeal and Brain Metastases as a First Reccurence Site in a Case with Germ Cell Testicular Tumor

Patients with testicular germ cell tumors (TGCT) usually presented with a testicular mass and retroperitoneal lymph nodes metastases, but brain and leptomeningeal metastases are rarely encountered in oncology practice. There are not any proven treatment options for relapsing TGCT with brain or leptomeningeal metastasis. We herein present a rare case of TGCT of brain and leptomeningeal metastasis as a first sign of recurrence with literature review.

___

  • 1. https://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-staging-of-testicular-germ-cell-tumors
  • 2. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin 2021; 71:7.
  • 3. Feldman, D.R., Lorch, A., Kramar, A. et al. Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options—An Analysis From the Global Germ Cell Cancer Group. J Clin Oncol. 2016.34, 345–351. https://doi.org/10.1200/JCO.2015.62. 7000.
  • 4. Hinton S, Catalano PJ, Einhorn LH, et al. Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial. Cancer 2003; 97:1869.
  • 5. Kalra, M., Adra, N., Hanna, N., Abonour, R., Einhorn, L.H., 2020. High‐dose chemotherapy plus peripheral blood stem cell transplantation for patients with relapsed germ cell tumors and active brain metastases. Cancer 126, 1202–1207. https://doi. org/10.1002/cncr.32628.
  • 6. Jeong YB. Wang KC. Phi JH. et al. A Case of Nongerminomatous Germ Cell Tumor with Fulminant Course Concomitant Leptomeningeal Metastasis Brain Tumor Res Treat 2016;4:21-25. http://dx.doi.org/10.14791/btrt.2016.4.1.21
Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 1300-6622
  • Yayın Aralığı: 3
  • Başlangıç: 2015
  • Yayıncı: -
Sayıdaki Diğer Makaleler

Marfan Sendromu Hastada Non-Koroner Sinüs Valsalvanın Dev Anevrizması

Yılmaz YOZGAT, Abdullah ERDEM, Amir AGHAYEV, Emre ÖTEYAKA, Gizem SARI, Mehmet Turan BASUNLU, Mustafa Özer ULUKAN, Atalay KARAKAYA, Murat UĞURLUCAN, Halil TÜRKOĞLU

Dokuz Eylül Üniversitesi Tıp Fakültesi’nde Mesleksel Değerler ve Etik Eğitimi (1997-2019)

Ahmet Can BİLGİN, Sema ÖZAN, Cemal Hüseyin GÜVERCİN, Salih Semih ŞEMİN

COVID-19 SOKAĞA ÇIKMA KISITLAMASI SÜRESİNCE ÇOCUKLARDA YABANCI CİSİM ASPİRASYONLARI; YASAKLAR ÇOCUKLARA ZARARLI MI?

Sevim ÇAKAR, Gülin ERDEMİR EREN, Cahit Barış ERDUR, Kübra Evren ŞAHİN, Çiğdem Ömür ECEVİT, Özlem BEKEM

Koagülasyon Testlerinde Altı Sigma Yöntemi ve Değerlendirilmesi

Mert ÜĞE, Mehmet Hicri KÖSEOĞLU, Serap ÇUHADAR, Figen NARİN

Erişkinlerde serum kobalamin düzeyinin yüksekliği ileri tetkik veya takip gerektirir mi?

Işıl ERDOĞAN ÖZÜNAL, Taner TAN, Erman ÖZTÜRK

Sağlık Hizmetleri Meslek Yüksekokulu öğrencilerinin geleneksel ve tamamlayıcı tıp ve ilişkili enfeksiyon kontrol önlemleri hakkında bilgi düzeylerinin incelenmesi

Aysun ÖZLÜ, Sevil ALKAN, Emine Kübra DİNDAR DEMİRAY, Hatice ÖNTÜRK, Şebnem ŞENOL AKAR

Treatment Management of Leptomeningeal and Brain Metastases as a First Reccurence Site in a Case with Germ Cell Testicular Tumor

Sabin GÖKTAŞ AYDIN, Ahmet BİLİCİ, Aslı ÇAKIR, Ömer Fatih ÖLMEZ, Ayşenur CİLA, Dilek ÜNAL

Yutma Fonksiyonunun Merkezi Kontrolü

Selen SEREL ARSLAN, Yağmur ELMALI

Foreign body ingestions in children during COVID-19 lockdown; was it harmful for children?

Sevim ÇAKAR

Evaluation of adult patients with hereditary spherocytosis

Emrah KILIÇASLAN, Selim SAYIN, Murat YILDIRIM, Tayfun ELİBOL, Hilmi Erdem GÖZDEN, Meltem AYLI, Muhammet Kürşat KAPTAN