BENHUR ŞİRVAN ÇETİN, MUSTAFA KIR, Nurettin ÜNAL, TUNCAY KÜME, NUH YILMAZ

Soldan sağa şantlı doğumsal kalp hastalıklı çocuklarda şant miktarı ile kardiyotrofin–1 ilişkisi

Amaç: Çalışmamızda çocuklarda soldan sağa şantlı doğumsal kalp hastalıklarında serum kardiyotrofin-1 (CT-1) düzeyleri ile şant miktarının karşılıklı etkileşimlerini araştırmak, bu belirtecin intrakardiyak defekt tipine göre değişimlerini incelemek amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda, 1 ay–13 yaşları arasında, 45 hasta ve 23 sağlıklı çocuk incelendi. Hasta grubu içinde 19 olguda atriyal septal defekt (ASD), 17 olguda ventriküler septal defekt (VSD), 6 olguda ASD ve VSD (ASD+VSD) ve 3 olguda patent duktus arteriyozus (PDA) mevcuttu. Tüm çocuklara konvansiyonel ekokardiyografi incelemesi (iki boyutlu, M-Mode, iki boyutlu Doppler ve renkli Doppler ekokardiyografileri) yapıldı. Tüm olgulardan ekokardiyografi çalışmaları ile eş zamanlı olarak plazma BNP düzeyleri kemilüminisans ve CT-1 düzeyleri de “enzyme-linked immunosorbent assay” (ELISA) yöntemleriyle ölçüldü. Bulgular: Hasta grubunda CT-1 ile şant miktarı arasında (p

THE RELATIONSHIP BETWEEN LEFT TO RIGHT SHUNTING CONGENITAL HEART DISEASE AND CARDIOTROPHIN-1 IN CHILDREN

Objective: In our study, it was aimed to investigate the interaction of serum cardiotrophin-1 (CT-1) levels in left to right shunting congenital heart disease in children and to evaluate the change of this biomarker with intracardiac defect features.Material and Method: We investigated 45 patients and 23 healthy children between 1 months and 13 years of age in our study. In the patient group, we identified an atrial septal defect (ASD) in 19 cases, a ventricular septal defect (VSD) in 17 cases, an ASD and VSD (ASD+VSD) in 6 cases and a patent ductus arteriosus (PDA) in 3 cases. All children underwent a classical echocardiography (twodimensional, M-Mode, two-dimensional Doppler and colour Doppler echocardiography). In all patients, plasma BNP levels were measured by chemiluminescence and CT-1 levels were estimated by enzyme-linked immunosorbent assay (ELISA) method, synchronously with echocardiographic studies. Results: A positive correlation was detected between CT-1 and the number of shunts (p

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